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https://w.atwiki.jp/idcos/pages/119.html
国試の時間割が大幅に変更され、コマ数が増えたことから、かねてから導入すべきとして検討（↓参照）されていた応用力試験（Skills analysis）が遂に導入されるかも知れません。 そんなに大層な試験形式ではないのですが、事前に知識があると、万が一本番で目にしても焦らずに済むかも知れません。 そもそもSkills Analysisとは何か？ 例題をアップしておきます（passは大学名、英小文字半角6文字）。上手くコピーできなかったので右端が汚くて申し訳ありません。参考にしてください。（因みに元ネタは『日本医師会雑誌123巻第4号、p507-516,2000』） 例題は国試ガイドライン（有料）にも載っています。ネットで手に入る無料版にはなぜか載っていません。 医師国家試験改善検討委員会報告書について（平成１５年４月１７日） http //www.med.or.jp/student/kokushi_rep.html II．平成１７年（第９９回）の試験からの改善事項 １．改善に当たっての基本的な考え方 ２．改善すべき事項 （１）出題数・出題内容 （２）合否基準 （３）試験問題の公募、プール制（試験問題を出題する前にあらかじめ蓄えておくこと）の導入、試験問題の回収について （４）試験結果の通知 （５）出題形式 （６）応用力試験 応用力を問う問題の出題を強化するため、問題解釈型（タクソノミーII型）・問題解決型（タクソノミーIII型）の出題数が増加されつつあるが、今後も引き続き問題解釈型・問題解決型の出題や応用力試験（Skills analysis）の導入を考慮することが望ましい。
https://w.atwiki.jp/kojimakk/pages/26.html
Sequence Analysis 簡便なシーケンスエディタ。多少バグがあるように見受けられるが使用には問題ない。 無料でSequence Analysisから入手できる。 2008/0７４/1時点でのファイル名は、 SequenceAnalysis.dmg.gz Javaで書かれている。MacOSXでは10.3.3以降なら対応している。 解凍後ディスクイメージをダブルクリック。好きなフォルダに入れておけばそこからダブルクリックで動かせる。 Citations
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【登録タグ CD CDK くちばしPCD】 前作 本作 次作 どういうことなの！？ KUCHIBA CD 私の世界 くちばしP 流通 即売 同人 発売 2011年6月12日 価格 ￥1,000(税込) ￥1,470(税込) サークル キャットルミューティレーション 線形ネコ型システム CD紹介 くちばしPの歴史を総覧できそうなアルバム。全11曲収録。 ラストに収録されている「私の世界」は、名曲「私の時間」の歌詞を変えた リメイクver. THE VOC@LOiD M@STER 16（ボーマス16）で初頒布。とらのあな専売で委託もされている。 曲目 ALYSS New! すてねこっと ナイトメア☆パーティーナイト となりのカミサマ HEAVENS OF DARKNESS どういうことなの！？ 恋愛部活動記録 雪晴れ Sr. Wonderland マッシュルーム戦争 私の世界 New! リンク CD特設ページ 世は混沌へと帰す（くちばしPのブログ） とらのあな コメント ＡＬＹＳＳいい曲ですよね！ -- るる (2012-05-26 20 39 33) 名前 コメント
https://w.atwiki.jp/metalmetabo/pages/25.html
- visitors Metabolic pathway analysis basic concepts and scientific applications in the post-genomic erapsu.edu [PDF] CH Schilling, S Schuster, BO Palsson, … - Biotechnology …, 1999 - interscience.wiley.com http //scholar.google.com/scholar?q=related JkHo1UMnlWkJ scholar.google.com/ hl=ja as_sdt=2000 This article reviews the relatively short history of metabolic pathway analysis. Computer-aided algorithms for the synthesis of metabolic pathways are discussed. Important algebraic concepts used in pathway analysis, such as null space and convex cone, are explained. It is ... Metabolic pathway analysisS Schuster - Information and Simulation Systems for the Analysis of … - Citeseer http //citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.94.4013 rep=rep1 type=pdf#page=18 18 Metabolic pathway analysis Stefan Schuster Max Delbruck Centre for Molecular Medicine D-13092 Berlin-Buch, Germany Metabolic network analysis, alternatively called pathway analysis, has manifold applications in functional genomics, metabolic engineering and ... Two approaches for metabolic pathway analysis? tkk.fi [PDF]S Klamt, J Stelling - TRENDS in Biotechnology, 2003 - Elsevier http //scholar.google.com/scholar?q=related Zqc2nsalEsAJ scholar.google.com/ hl=ja as_sdt=2000 Metabolic pathway analysis is becoming increasingly important for assessing inherent network properties in (reconstructed) biochemical reaction networks. Of the two most promising concepts for pathway analysis, one relies on elementary flux modes and the other on extreme ... Theory for the systemic definition of metabolic pathways and their use in interpreting metabolic function from a pathway-oriented perspective CH Schilling, D Letscher, BØ PALSSON - Journal of Theoretical Biology, 2000 - Elsevier http //scholar.google.com/scholar?q=related 5zrGtYrEQUQJ scholar.google.com/ hl=ja as_sdt=2000 ... 4193–4198. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (78). 25. CH SCHILLING, S. SCHUSTER, BO PALSSON and R. HEINRICH, Metabolic pathway analysis basic concepts and scientific applications in the post-genomic era. Biotechnol. Prog. ... A multiple alignment algorithm for metabolic pathway analysis using enzyme hierarchy Y Tohsato, H Matsuda, A Hashimoto - Proceedings of the 8th International …, 2000 - aaai.org http //scholar.google.com/scholar?q=related Gyor1EbInm8J scholar.google.com/ hl=ja as_sdt=2000 In many of the chemical reactions in living cells, enzymes act as catalysts in the conversion of certain compounds (substrates) into other compounds (products). Comparative analyses of the metabolic pathways formed by such reactions give important information on their ... Metabolic pathway analysis of a recombinant yeast for rational strain development brookes.ac.uk [PDF]R Carlson, D Fell, F Srienc - Biotechnology and …, 2002 - interscience.wiley.com http //scholar.google.com/scholar?q=related oWtlgoIqVyQJ scholar.google.com/ hl=ja as_sdt=2000 Abstract Elementary mode analysis has been used to study a metabolic pathway model of a recombinant Saccharomyces cerevisiae system that was genetically engineered to produce the bacterial storage compound poly-b-hydroxybutyrate (PHB). The model includes bio- ... Metabolic pathway analysis web service (Pathway Hunter Tool at CUBIC) oxfordjournals.org [HTML]SA Rahman, P Advani, R Schunk, R Schrader, D … - …, 2005 - Oxford Univ Press http //scholar.google.com/scholar?q=related MgbBoNOqvX8J scholar.google.com/ hl=ja as_sdt=2000 Motivation Pathway Hunter Tool (PHT), is a fast, robust and user-friendly tool to analyse the shortest paths in metabolic pathways. The user can perform shortest path analysis for one or more organisms or can build virtual organisms (networks) using enzymes. Using PHT, the ... Combined use of proteomic analysis and enzyme activity assays for metabolic pathway analysis of glycerol fermentation by Klebsiella pneumoniae tu-harburg.de [PDF]W Wang, J Sun, M Hartlep, WD … - Biotechnology and …, 2003 - interscience.wiley.com http //scholar.google.com/scholar?q=related OKsyM7nYUH0J scholar.google.com/ hl=ja as_sdt=2000 Abstract The fed-batch fermentation of glycerol to 1,3- propanediol by Klebsiella pneumoniae displayed an un- usual dynamic behavior that can be clearly divided into four distinct phases according to cell growth and CO2 evolution rate. Metabolism changed significantly during ... Combinatorial complexity of pathway analysis in metabolic networks u-bordeaux2.fr [PDF]S Klamt, J Stelling - Molecular Biology Reports, 2002 - Springer http //scholar.google.com/scholar?q=related kLqNimyG924J scholar.google.com/ hl=ja as_sdt=2000 Key words combinatorial complexity in metabolic networks, elementary flux modes, metabolic pathway analysis, structural network analysis Summary Elementary flux mode analysis is a promising approach for a pathway ... Comparison of network-based pathway analysis methods cell.com [HTML]JA Papin, J Stelling, ND Price, S Klamt, S … - TRENDS in …, 2004 - Elsevier http //scholar.google.com/scholar?q=related BYENm_cYtdQJ scholar.google.com/ hl=ja as_sdt=2000 ... Recent network-based metabolic pathway analysis has focused on two approaches, those of elementary modes [4] and extreme pathways [5]. Both of these methods use convex analysis [6], a branch of mathematics that enables the analysis of inequalities and systems of linear ...
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- visitors Metabolic pathway analysis of enzyme-deficient human red blood cells T ÇakIr, CS Tacer, KÖ Ülgen - Biosystems, 2004 - Elsevier http //scholar.google.com/scholar?q=related 8w1qIgoYqGcJ scholar.google.com/ hl=ja as_sdt=2000 Five enzymopathies (G6PDH, TPI, PGI, DPGM and PGK deficiencies) in the human red blood cells are investigated using a stoichiometric modeling approach, ie, metabolic pathway analysis. Elementary flux modes (EFMs) corresponding to each enzyme deficiency case ... Reconstruction of metabolic networks from genome data and analysis of their global structure for various organisms oxfordjournals.org [PDF]H Ma, AP Zeng - Bioinformatics, 2003 - Oxford Univ Press http //scholar.google.com/scholar?q=related SuHZgSLeNw8J scholar.google.com/ hl=ja as_sdt=2000 Page 1. BIOINFORMATICS Vol. 19 no. 2 2003 Pages 270–277 Reconstruction of metabolic networks from genome data and analysis of their global structure for various organisms Hongwu Ma1, 2 and An-Ping Zeng1,∗ 1GBF ... Elementary mode analysis a useful metabolic pathway analysis tool for characterizing cellular metabolism CT Trinh, A Wlaschin, F Srienc - Applied microbiology and biotechnology, 2009 - Springer http //scholar.google.com/scholar?q=related hkaWpJnxK5QJ scholar.google.com/ hl=ja as_sdt=2000 Abstract Elementary mode analysis is a useful metabolic pathway analysis tool to identify the structure of a metabolic network that links the cellular phenotype to the corresponding genotype. The analysis can decompose the intricate metabolic network comprised of ... Extreme pathway analysis of human red blood cell metabolism nih.gov [PDF]SJ Wiback, BO Palsson - Biophysical Journal, 2002 - Elsevier http //scholar.google.com/scholar?q=related hVaLEfzPgSEJ scholar.google.com/ hl=ja as_sdt=2000 Constraints-based models regulation of gene expression reduces the steady-state solution space MW Covert, BO Palsson - Journal of theoretical Biology, 2003 - Elsevier http //scholar.google.com/scholar?q=related o9VRtN2gAKQJ scholar.google.com/ hl=ja as_sdt=2000 ... Biol. 203, 249, 283. 26. CH SCHILLING, S. SCHUSTER, BO PALSSON and R.HEINRICH, Metabolic pathway analysis basic concepts and scientific applications in the post-genomic era. Biotechnol. Prog. 15 (1999), pp. 296–303. ... The JAK-STAT signaling network in the human B-cell an extreme signaling pathway analysis nih.gov [HTML]JA Papin, BO Palsson - Biophysical Journal, 2004 - Elsevier http //scholar.google.com/scholar?q=related myiNLachV-QJ scholar.google.com/ hl=ja as_sdt=2000 From genome to cellular phenotype—a role for metabolic flux analysis? A Cornish-Bowden, ML Cárdenas - Nature Biotechnology, 2000 - nature.com http //scholar.google.com/scholar?q=related Q1z877WO_uAJ scholar.google.com/ hl=ja as_sdt=2000 ... whether a bypass exists within a complex network. Metabolic pathway analysis aims to identify indispensable enzymes, thus predicting the effects of their deletion or inhibition. Flux analysis should also allow the determination ... On-line metabolic pathway analysis based on metabolic signal flow diagram H Shi, K Shimizu - Biotechnology and bioengineering, 1998 - interscience.wiley.com http //scholar.google.com/scholar?q=related wjDdrq_SGcQJ scholar.google.com/ hl=ja as_sdt=2000 Abstract In this work, an integrated modeling approach based on a metabolic signal flow diagram and cellular energetics was used to model the metabolic pathway analysis for the cultivation of yeast on glucose. This ap- proach enables us to make a clear analysis of the flow ... Metabolic pathway analysis of recombinant Saccharomyces cerevisiae with a galactose-inducible promoter based on a signal flow modeling approach S Jin, K Ye, K Shimizu - Journal of Fermentation and Bioengineering, 1995 - Elsevier http //scholar.google.com/scholar?q=related 0uzMsbsJrXEJ scholar.google.com/ hl=ja as_sdt=2000 The objective of this work was to develop a signal flow diagram-based modeling approach proposed by Endo et al. (1976) to organize the network of complex metabolic reactions occurring in the living cell, employing directed signal flow diagram in which the enzyme reaction ... Energy balance for analysis of complex metabolic networks nih.gov [PDF]DA Beard, S Liang, H Qian - Biophysical journal, 2002 - Elsevier http //scholar.google.com/scholar?q=related wcAvs5fp3FgJ scholar.google.com/ hl=ja as_sdt=2000
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- visitors In vivo analysis of intracellular amino acid labelings by GC/MS. C Wittmann, M Hans, E Heinzle - Analytical biochemistry, 2002 - mendeley.com ... TBDMS derivatization of amino acids is especially useful in metabolic network analysis, because M-57 fragments containing the entire carbon skeleton of the analyte can be observed by GC/MS with high signal intensities 8. The potential of the method is exemplified for ... Comparative metabolic flux analysis of lysine-producing Corynebacterium glutamicum cultured on glucose or fructose nih.gov [HTML]P Kiefer, E Heinzle, O Zelder, C … - Applied and …, 2004 - Am Soc Microbiol ... A comprehensive approach to 13 C tracer studies, labeling measurements by gas chromatography-mass spectrometry, metabolite balancing, and isotopomer modeling, was applied for comparative metabolic network analysis of lysine-producing Corynebacterium glutamicum ... It is all about metabolic fluxes nih.gov [HTML]J Nielsen - Journal of bacteriology, 2003 - Am Soc Microbiol http //scholar.google.com/scholar?q=related xAvLLrdbbNYJ scholar.google.com/ hl=ja as_sdt=2000 ... I. Experimental observations. Biotechnol. Bioeng. 55 305-316.[CrossRef] 21; Thykaer, J., B. Christensen, and J. Nielsen. 2002. Metabolic network analysis of an adipoyl-7-ADCA producing strain of Penicillium chrysogenum elucidation of adipate degradation.Metab. Eng. ... Using topology of the metabolic network to predict viability of mutant strains biomedcentral.com [PDF]Z Wunderlich, L Mirny - Genome Biology, 2005 - biomedcentral.com http //scholar.google.com/scholar?q=related sTavonuje7wJ scholar.google.com/ hl=ja as_sdt=2000 ... Ph.D. Thesis. University of Leeds; 1994. 14. Papp B, Pal C, Hurst LD Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast. Nature 2004, 429(6992) 661-664. 15. Jeong H, Tombor B, Albert R, Oltvai ZN, Barabasi AL The large-scale ... Novel proteins, putative membrane transporters, and an integrated metabolic network are revealed by quantitative proteomic analysis of Arabidopsis cell … plantphysiol.org [HTML]H Eubel, EH Meyer, NL Taylor, JD Bussell, N O … - Plant …, 2008 - Am Soc Plant Biol http //scholar.google.com/scholar?q=related aCgbR-dAtyMJ scholar.google.com/ hl=ja as_sdt=2000 ... This is aided by a metabolic network analysis that reveals a tight integration of functions and highlights specific metabolite nodes that most probably represent entry and exit metabolites that could require transport across the peroxisomal membrane. ... High-throughput phenomics experimental methods for mapping fluxomes bjmu.cn [PDF]U Sauer - Current opinion in Biotechnology, 2004 - Elsevier http //scholar.google.com/scholar?q=related XvhSxXXwbn4J scholar.google.com/ hl=ja as_sdt=2000 ... From its early days when material fluxes were balanced within assumed reaction networks [7.], metabolic network analysis [6. and 8.] has matured to actually identify the topology of active reactions and pathways and to quantify the molecular flux through them on a variety of ... Use of genome-scale microbial models for metabolic engineering KR Patil, M Åkesson, J Nielsen - Current opinion in biotechnology, 2004 - Elsevier http //scholar.google.com/scholar?q=related oAOz5SBTVHAJ scholar.google.com/ hl=ja as_sdt=2000 ... incorporate genome-scale biological data. Genome-scale stoichiometric models of microorganisms represent a first step in this direction. FBA, flux balance analysis; MFA, metabolic flux analysis; MNA, metabolic network analysis. ... Network identification and flux quantification in the central metabolism of Saccharomyces cerevisiae under different conditions of glucose repression nih.gov [HTML]AK Gombert, M Moreira dos Santos, B … - Journal of …, 2001 - Am Soc Microbiol http //scholar.google.com/scholar?q=related R5V_AodxCrwJ scholar.google.com/ hl=ja as_sdt=2000 ... flux estimates. The use of 13 C-labeled substrates enables both identification of the metabolic network structure and quantification of the metabolic fluxes and is therefore referred to as metabolic network analysis (5). This kind ... Metabolic flux analysis of Escherichia coli K12 grown on 13C-labeled acetate and glucose using GC-MS and powerful flux calculation method freelogy.org [PDF]J Zhao, K Shimizu - Journal of biotechnology, 2003 - Elsevier http //scholar.google.com/scholar?q=related w1m-5IKYKpsJ scholar.google.com/ hl=ja as_sdt=2000 Structural and functional analysis of cellular networks with CellNetAnalyzer biomedcentral.com [HTML]S Klamt, J Saez-Rodriguez, ED Gilles - BMC Systems Biology, 2007 - biomedcentral.com http //scholar.google.com/scholar?q=related bzwlVku0FL8J scholar.google.com/ hl=ja as_sdt=2000 ... CNA extends its predecessor FluxAnalyzer, originally developed for metabolic network analysis[7], by new methods for signalling and regulatory networks, ie for networks where signal flows are dominating (in contrast to mass flows in metabolic networks). ...
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初投稿 いきなりですが 疲れたときにこそ リラックスできる 場所が欲しいと思って 自分のブログというものを開設しました(#^.^#) 気ままに更新するつもりです 皆様よろしくお願いします
https://w.atwiki.jp/metalmetabo/pages/32.html
- visitors Development of network-based pathway definitions the need to analyze real metabolic networks nhahocotton.org.vn [PDF]BO Palsson, ND Price, JA Papin - Update, 2003 - nhahocotton.org.vn http //scholar.google.com/scholar?q=related RJrIZTi52eQJ scholar.google.com/ hl=ja as_sdt=2000 ... A recent article [1] addresses the important issue of network-based metabolic pathway analysis. ... References 1 Klamt, S. and Stelling, J. (2003) Two approaches for metabolic pathway analysis? Trends Biotechnol. 21, 64–69 2 Karp, PD et al. ... PathFinder reconstruction and dynamic visualization of metabolic pathways oxfordjournals.org [PDF]A Goesmann, M Haubrock, F Meyer, J … - …, 2002 - Oxford Univ Press http //scholar.google.com/scholar?q=related tN609hXVn9QJ scholar.google.com/ hl=ja as_sdt=2000 ... database. Nucleic Acids Res., 26, 43–45. Tohsato,Y., Matsuda,H. and Hashimoto,A.(2000) A multiple align- ment algorithm for metabolic pathway analysis using enzyme hierarchy. Proceedings, ISMB 2000. pp. 376–383. Wackett ... Toward metabolic phenomics analysis of genomic data using flux balances dss.go.th [PDF]CH Schilling, JS Edwards, BO … - Biotechnology progress, 1999 - Wiley Online Library http //scholar.google.com/scholar?q=related 5xFNmiGLuFoJ scholar.google.com/ hl=ja as_sdt=2000 ... This approach of metabolic pathway analysis accompanied with FBA techniques can allow one to assess the basic structural capabilities and fitness of an organism as a result of the pathways that are theoretically present within the cell. ... Robustness Analysis of the Escherichiacoli Metabolic Network dss.go.th [PDF]JS Edwards, BO Palsson - Biotechnology Progress, 2000 - interscience.wiley.com http //scholar.google.com/scholar?q=related F73ImcZpznMJ scholar.google.com/ hl=ja as_sdt=2000 Page 1. Robustness Analysis of the Escherichia coli Metabolic Network Jeremy S.Edwards† and Bernhard O. Palsson* Department of Bioengineering, University of California-San Diego, La Jolla, California 92093-0412 Genomic ... FluxAnalyzer exploring structure, pathways, and flux distributions in metabolic networks on interactive flux maps oxfordjournals.org [PDF]S Klamt, J Stelling, M Ginkel, ED Gilles - Bioinformatics, 2003 - Oxford Univ Press http //scholar.google.com/scholar?q=related vOydM3d06iMJ scholar.google.com/ hl=ja as_sdt=2000 ... additionally reversibility and capacity restrictions for each reaction. Metabolic Pathway Analysis (MPA) searches for meaningful structural and functional units in metabolic networks. The two most promising, very similar ap- proaches ... Integrating cybernetic modeling with pathway analysis provides a dynamic, systems-level description of metabolic control JD Young, KL Henne, JA Morgan, AE … - Biotechnology and …, 2008 - interscience.wiley.com http //scholar.google.com/scholar?q=related SiQjLbrsCw4J scholar.google.com/ hl=ja as_sdt=2000 ... biochemical networks. Combining cybernetic control laws with concepts from metabolic pathway analysis has culminated in a sys- tematic strategy for constructing cybernetic models, which was previously lacking. The newly ... Exploring the pathway structure of metabolism decomposition into subnetworks and application to Mycoplasma pneumoniae oxfordjournals.org [PDF]S Schuster, T Pfeiffer, F Moldenhauer, I Koch, T … - …, 2002 - Oxford Univ Press http //scholar.google.com/scholar?q=related o1Qpi78HxmoJ scholar.google.com/ hl=ja as_sdt=2000 Page 1. BIOINFORMATICS Vol. 18 no. 2 2002 Pages 351–361 Exploring the pathway structure of metabolism decomposition into subnetworks and application to Mycoplasma pneumoniae S. Schuster 1 , T. Pfeiffer 2 , F. Moldenhauer 1 , I. Koch 3 and T. Dandekar 4, 5 ... The complete genome sequence of the gastric pathogen Helicobacter pylori JF Tomb, O White, AR Kerlavage, RA Clayton, GG … - Nature, 1997 - nature.com http //scholar.google.com/scholar?q=related Eo36dy8hFLcJ scholar.google.com/ hl=ja as_sdt=2000 ... Top of page Metabolism. Metabolic pathway analysis of the H. pylori genome suggests the following features. H. pylori uses glucose as the only source of carbohydrate and the main source for substrate-level phosphorylation. ... Deriving phylogenetic trees from the similarity analysis of metabolic pathways oxfordjournals.org [PDF]M Heymans, AK Singh - Bioinformatics, 2003 - Oxford Univ Press http //scholar.google.com/scholar?q=related Y2vvexN5fz8J scholar.google.com/ hl=ja as_sdt=2000 Page 1. BIOINFORMATICS Vol. 19 Suppl. 1 2003, pages i138–i146 DOI 10.1093/bioinformatics/btg1018 Deriving phylogenetic trees from the similarity analysis of metabolic pathways Maureen Heymans and Ambuj K. Singh ∗ ... Treatment of multifunctional enzymes in metabolic pathway analysis S Schuster, I Zevedei-Oancea - Biophysical chemistry, 2002 - Elsevier http //scholar.google.com/scholar?q=related G_O7SiZhvKsJ scholar.google.com/ hl=ja as_sdt=2000 In metabolic pathway analysis, it should be considered that many enzymes operate with low specificity (eg nucleoside diphosphokinase, uridine kinase, transketolase, aldolase), so that various substrates and products can be converted. Here, we analyze the effect of ...
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- visitors Application of regulatory sequence analysis and metabolic network analysis to the interpretation of gene expression data psu.edu [PDF]J Van Helden, D Gilbert, L Wernisch, M Schroeder, … - Computational …, 2001 - Springer http //scholar.google.com/scholar?q=related JS_4j3CP5nEJ scholar.google.com/ hl=ja as_sdt=2000 Comparative metabolic network analysis of two xylose fermenting recombinant Saccharomyces cerevisiae strains T Grotkjær, P Christakopoulos, J Nielsen, L … - Metabolic Engineering, 2005 - Elsevier http //scholar.google.com/scholar?q=related m6nOh8HQbaIJ scholar.google.com/ hl=ja as_sdt=2000 The recombinant xylose fermenting strain Saccharomyces cerevisiae TMB3001 can grow on xylose, but the xylose utilisation rate is low. One important reason for the inefficient fermentation of xylose to ethanol is believed to be the imbalance of redox co-factors. In the present ... The Edinburgh human metabolic network reconstruction and its functional analysis nih.gov [HTML]H Ma, A Sorokin, A Mazein, A Selkov, E … - Molecular systems …, 2007 - nature.com http //scholar.google.com/scholar?q=related pgWLepUKeS0J scholar.google.com/ hl=ja as_sdt=2000 ... A main objective of human metabolic network analysis is to see how it is related with human disease. More than 10 000 human genes (half of the whole genome) have been reported to be related with one or more human diseases in the OMIM database (Hamosh et al, 2005). ... Reconstruction of metabolic networks from genome data and analysis of their global structure for various organisms oxfordjournals.org [PDF]H Ma, AP Zeng - Bioinformatics, 2003 - Oxford Univ Press http //scholar.google.com/scholar?q=related SuHZgSLeNw8J scholar.google.com/ hl=ja as_sdt=2000 ... It is one of the main tasks of metabolic network analysis to find possible conversion pathways between two metabolites. There may be many different pathways between two metabolites, among them the shortest pathway is of particular interest for network analysis. ... Metabolic network analysis of an adipoyl-7-ADCA-producing strain of Penicillium chrysogenum elucidation of adipate degradation J Thykaer, B Christensen, J Nielsen - Metabolic Engineering, 2002 - Elsevier http //scholar.google.com/scholar?q=related gycTvJYwT9kJ scholar.google.com/ hl=ja as_sdt=2000 An adipoyl-7-ADCA-producing, recombinant strain of Penicillium chrysogenum was characterized by metabolic network analysis, with special focus on the degradation of adipate and determination of the metabolic fluxes. Degradation of the side-chain precursor, adipate, causes an ... Potential metabolic limitations in lysine production by Corynebacterium glutamicum as revealed by metabolic network analysis JA Hollander - Applied Microbiology and Biotechnology, 1994 - Springer http //scholar.google.com/scholar?q=related BwIeARCnafMJ scholar.google.com/ hl=ja as_sdt=2000 Corynebacterium glutamicum and closely related Brevi- bacterium species are the most important organisms used for the industrial fermentative production of ly- sine. Although wild-type strains do not excrete lysine at all, classical mutation programs have resulted in strains ... Metabolic flux and metabolic network analysis of Penicillium chrysogenum using 2D [13C, 1H] COSY NMR measurements and cumulative bondomer simulation WA van Winden, WM van Gulik, D … - Biotechnology and …, 2003 - Wiley Online Library http //scholar.google.com/scholar?q=related Jy6SBrqyeHAJ scholar.google.com/ hl=ja as_sdt=2000 Abstract At present two alternative methods are avail- able for analyzing the fluxes in a metabolic network (1) combining measurements of net conversion rates with a set of metabolite balances including the cofactor bal- ances, or (2) leaving out the cofactor balances and fitting the ... Metabolic‐flux and network analysis in fourteen hemiascomycetous yeasts LM Blank, F Lehmbeck, U Sauer - FEMS yeast research, 2005 - Wiley Online Library http //scholar.google.com/scholar?q=related ILl2ugZn3ZcJ scholar.google.com/ hl=ja as_sdt=2000 ... (5). Oxaloacetate14 mit was estimated using Eq. (6)[16] (6). 2.6Metabolic-network analysis. We used a previously constructed metabolic network [1,24], which consists of the PP pathway, glycolysis, TCA cycle, gluconeogenesis, malic enzyme and by-product formation reactions. ... 13C metabolic flux analysis W Wiechert - Metabolic Engineering, 2001 - Elsevier http //scholar.google.com/scholar?q=related Eat1pl-yJGQJ scholar.google.com/ hl=ja as_sdt=2000 ... 6. B. Christensen and J. Nielsen, Metabolic network analysis, a powerful tool in metabolic engineering. Adv. Biochem. Eng. ... 209–231. 7. B. Christensen and J. Nielsen, Metabolic network analysis of Penicillium chrysogenum using 13 C-labeled glucose. Biotechnol. Bioeng. ... Multiple knockout analysis of genetic robustness in the yeast metabolic network tau.ac.il [PDF]D Deutscher, I Meilijson, M Kupiec, E Ruppin - Nature genetics, 2006 - nature.com http //scholar.google.com/scholar?q=related X5cH6RUwUF0J scholar.google.com/ hl=ja as_sdt=2000 ... | PubMed |; Kitano, H. Biological robustness. Nat. Rev. Genet. 5, 826–837 (2004). | Article | PubMed | ISI | ChemPort |; Papp, B. , Pál, C. Hurst, LD Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast. Nature 429, 661–664 (2004). ...
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- visitors Combining pathway analysis with flux balance analysis for the comprehensive study of metabolic systems slu.edu [PDF]… JS Edwards, D Letscher, BØ Palsson - Biotechnology and …, 2000 - interscience.wiley.com http //scholar.google.com/scholar?q=related HtFdZ3DFTgMJ scholar.google.com/ hl=ja as_sdt=2000 ... dimensional space. From metabolic pathway analysis, the edges of the high-dimensional flux cone are vectors that correspond to sys- temically defined “extreme pathways” spanning the ca- pabilities of the system. The addition ... Metabolic pathway analysis of yeast strengthens the bridge between transcriptomics and metabolic networks T Çakir, B Kirdar, KÖ Ülgen - Biotechnology and …, 2004 - Wiley Online Library http //scholar.google.com/scholar?q=related cUtrabByB40J scholar.google.com/ hl=ja as_sdt=2000 Abstract Central carbon metabolism of the yeast Saccha- romyces cerevisiae was analyzed using metabolic pathway analysis tools. Elementary flux modes for three substrates (glucose, galactose, and ethanol) were determined using the catabolic reactions ... Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum JO Krömer, C Wittmann, H Schröder, E Heinzle - Metabolic engineering, 2006 - Elsevier http //scholar.google.com/scholar?q=related KSxlsQoF_oIJ scholar.google.com/ hl=ja as_sdt=2000 Metabolic pathway analysis was carried out to predict the metabolic potential of Corynebacterium glutamicum and Escherichia coli for the production of L-methionine. Based on detailed stoichiometric models for these organisms, this allowed the calculation of the theoretically optimal ... The genome-scale metabolic extreme pathway structure in Haemophilus influenzae shows significant network redundancy JA Papin, ND Price, JS Edwards, BØ … - Journal of theoretical …, 2002 - Elsevier http //scholar.google.com/scholar?q=related KrUkw9kndisJ scholar.google.com/ hl=ja as_sdt=2000 ... 229–248. Abstract | PDF (428 K) | View Record in Scopus | Cited By in Scopus (198). 19. CHSCHILLING, S. SCHUSTER, BO PALSSON and R. HEINRICH, Metabolic pathway analysis basic concepts and scientific applications in the post-genomic era. Biotechnol. Prog. ... Potential drug targets in Mycobacterium tuberculosis through metabolic pathway analysis psu.edu [PDF]S Anishetty, M Pulimi, G Pennathur - Computational Biology and …, 2005 - Elsevier http //scholar.google.com/scholar?q=related hEJbAmAPhwkJ scholar.google.com/ hl=ja as_sdt=2000 The emergence of multidrug resistant varieties of Mycobacterium tuberculosis has led to a search for novel drug targets. We have performed an insilico comparative analysis of metabolic pathways of the host Homo sapiens and the pathogen M. tuberculosis. Enzymes from the ... In silico metabolic pathway analysis and design succinic acid production by metabolically engineered Escherichia coli as an example jsbi.org [PDF]SY Lee, SH Hong, SY Moon - GENOME INFORMATICS SERIES, 2002 - jsbi.org http //scholar.google.com/scholar?q=related 6Ehoy39R1HUJ scholar.google.com/ hl=ja as_sdt=2000 Abstract The intracellular metabolic fluxes can be calculated by metabolic flux analysis, which uses a stoichiometric model for the intracellular reactions along with mass balances around the intra- cellular metabolites. In this study, we have constructed in silico metabolic pathway ... Determination of redundancy and systems properties of the metabolic network of Helicobacter pylori using genome-scale extreme pathway analysis cshlp.org [HTML]ND Price, JA Papin, BØ Palsson - Genome Research, 2002 - genome.cshlp.org http //scholar.google.com/scholar?q=related hyQpOmehsTYJ scholar.google.com/ hl=ja as_sdt=2000 Metabolic pathway analysis in trypanosomes and malaria parasites. nih.gov [PDF]AH Fairlamb - Philosophical Transactions of the Royal Society B …, 2002 - ncbi.nlm.nih.gov http //scholar.google.com/scholar?q=related x44FtcJTlQwJ scholar.google.com/ hl=ja as_sdt=2000 Identification of novel drug targets is required for the development of new classes of drugs to overcome drug resistance and replace less efficacious treatments. In theory, knowledge of the entire genome of a pathogen identifies every potential drug target in any given microbe. ... A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks uni-erlangen.de [PDF]S Schuster, DA Fell, T Dandekar - Nature biotechnology, 2000 - nature.com http //scholar.google.com/scholar?q=related 4GmcRTKIXlwJ scholar.google.com/ hl=ja as_sdt=2000 ... Trends Biotechnol. 17, 53–60(1999). | Article | PubMed | ISI | ChemPort |; Schilling, CH, Schuster, S., Palsson, BO Heinrich R. Metabolic pathway analysis basic concepts and scientific applications in the post-genomic era. Biotechnol. Prog. 15, 296–303 (1999). ...