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https://w.atwiki.jp/artpath07senju/pages/23.html
ロゴ フリーペーパー用ロゴ ポスター・チラシ用ロゴ http //www41.atwiki.jp/artpath07senju/?cmd=upload act=listpage デザイン案 服部案(マッチ) デザインダメだし カラフル案の音環の文字情報がかなり読みにくいのと、千住ロゴが悪目立ちしているのが気になります。 -- 安川 (2007-11-14 18 52 50) カラフル案裏面の文が全体的に読みにくい。白面に白ロゴはわかりにくい。 -- 田中仁 (2007-11-14 22 38 48) 画像が表示されません。 -- 馬場 (2007-11-14 23 55 40) 同じく画像表示されません。 -- 遠藤 (2007-11-15 01 23 24) ブラウザの問題なのかも。Safariでは画像表示されたけどFireFoxだと表示されません。 -- 安川 (2007-11-15 09 52 11) マッチ案、千住と取手の日にちの間隔がせまくてわかりにくいかもしれません。 あと取手の曜日間違ってますよね。 -- 聞谷 (2007-11-15 14 13 48) マッチ好き -- 中新田 (2007-11-15 14 17 02) 名前 コメント 文章 「Art Pathとは?」 Art Path(アートパス)とは、東京芸術大学の取手・千住校地にて毎年行われている学生たちによる企画の名称であり、展覧会でもコンサートでもない「アートの小道」を表したいという願いが込められています。
https://w.atwiki.jp/rowamousou/pages/1625.html
【名前】The paper(ザ・ペーパー) 【性別】男 【年齢】30代 【職業】暗殺者 【特徴】どこにでもいるような平凡な男、特徴がないのが特徴 【好き】紙・トランプ 【嫌い】紙の質を下げるもの 【特技】紙の扱う物事全般・証拠隠滅 【趣味】折り紙・トランプマジック 【人間関係】 【詳細】 一部の裏社会で有名な暗殺者。誰に強制されるでもなく裏社会に入り、紙で人を殺すことが好きな狂人。 本名は捨てており、素性は誰にも分からない。常にどこかに紙を隠し持っており、出来るだけ隙を見せることはしないようにしている。 【備考】 彼の暗殺道具はどこにでもある普通の紙もしくはトランプ。 紙で指を切る現象を極限にまで分析、理解してことによりただの紙で人を真っ二つに斬る技術を手に入れている。カード手裏剣もできる。
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TaskPaper[編集] BUY APP WEBサイト サポート 名前 TaskPaper 価格 600円 バージョン 1.0.02010/02/13 同期 SimpleText.ws 検索 あり カレンダー表示 なし 回転 あり(ロック可) アラート なし バッジ なし アプリ連携 WriteRoomTextExpander タスク項目 ProjectsTasksNotesTags その他機能 備考
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Paperman 日付 対戦相手 MAP スコア 結果 SS 08/12/18 PMer ロボット工場 10-06 勝ち ■ 08/12/19 GM(ツワモノ) スラム街 03-00 勝ち ■ 08/12/21 男の子宣言 ロボット工場 09-10 負け ■ 08/12/23 Xtrap ロボット工場 01-10 負け なし 08/12/23 Xtrap ロボット工場 06-10 負け ■■ 08/12/23 Xtrap ロボット工場 06-10 負け ■■ 08/12/31 GUNSLINGER ロボット工場 10-01 勝ち ■■ 08/12/31 SIMPLE100「居酒屋」 ロボット工場 10-00 勝ち ■■ 09/01/01 Millytaly ロボット工場 04-10 負け ■■ 09/01/01 Millytaly ロボット工場 09-09 分け ■■ 09/01/01 マイケルジャクチョ ロボット工場 10-00 勝ち ■■ 09/01/01 ぴよぴよ ロボット工場 10-00 勝ち ■■ 09/01/02 Millytaly ロボット工場 06-08 負け ■■ 09/01/02 Millytaly ロボット工場 04-10 負け ■■ 09/01/02 adgj ロボット工場 10-05 勝ち ■■ 09/01/03 God×Paper ロボット工場 07-09 負け ■■ 09/01/03 God×Paper ロボット工場 10-02 勝ち ■■ 09/01/03 God×Paper ロボット工場 10-02 勝ち ■■ 09/01/03 リトルバスターズ ロボット工場 10-00 勝ち ■■ 09/01/03 DustBox-神葛- ロボット工場 10-01 勝ち ■■ 09/01/03 DustBox-神葛- スラム街 10-03 勝ち ■■ 09/01/03 Xtrap ロボット工場 07-08 負け ■■ 09/01/04 Xtrap ロボット工場 07-10 負け ■■ 09/01/04 Xtrap ロボット工場 08-06 勝ち ■■ 09/01/04 リトルバスターズ ロボット工場 10-01 勝ち ■■ 09/01/04 お鍋の食材 ロボット工場 10-01 勝ち ■■ 09/01/04 OVERKILL ロボット工場 10-00 勝ち ■■ 09/01/05 SIMPLE100「居酒屋」 ロボット工場 10-02 勝ち ■■ 09/01/05 HotCocoa ロボット工場 10-00 勝ち ■■ 09/01/05 野生のHIYAMA王国 ロボット工場 10-00 勝ち ■■ 09/01/05 Xtrap ロボット工場 07-10 負け ■■ 09/01/06 Xtrap ロボット工場 08-08 分け ■■ 09/01/11 Millytaly ロボット工場 07-07 分け ■■ 09/01/11 Millytaly ロボット工場 09-09 分け ■■ 09/01/14 淫媚会 ロボット工場 10-02 勝ち ■ 09/01/14 瞬間心重ねて・・・ ロボット工場 10-00 勝ち ■ 09/01/14 瞬間心重ねて・・・ ロボット工場 10-00 勝ち ■ 09/01/15 リトルバスターズ ロボット工場 10-03 勝ち ■■ 09/01/15 リトルバスターズ ロボット工場 10-04 勝ち ■■ 09/01/15 リトルバスターズ 魔法図書館 1k-1k 分け ■ 09/01/15 God×Paper ロボット工場 10-00 勝ち ■■ 09/01/15 God×Paper スラム街 10-01 勝ち ■■ 09/01/16 リトルバスターズ ロボット工場 10-01 勝ち ■■ 09/01/16 リトルバスターズ 魔法図書館 14-06 勝ち ■ 09/01/16 手乗りタイガー ロボット工場 10-00 勝ち ■■ 09/01/16 手乗りタイガー スラム街 05-00 勝ち ■ 09/01/16 God×Paper ロボット工場 10-05 勝ち ■■ 09/01/16 Millytaly ロボット工場 04-10 負け ■■ 09/01/16 Millytaly ロボット工場 02-10 負け ■■ 09/01/17 HotCocoa ロボット工場 10-01 勝ち ■
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U.L.Paper(United Liberty Paper)のミッション 日本語化してくれる方がいたらご協力お願いします。 ミッション名 難易度 クリア時間目安 アクション 説明 WRONG IS RIGHT 6.5/10 10分 カーチェイス 最初のセーフハウスのすぐ近くのOlegのマンションへ行く。誰もいないが電話でe-mailをチェックしろと言われるので調べる。なるべく速い車に乗って指定の場所へ移動。Oleg(オレグ)を追跡、殺害でミッション完了。 PORTRAIT OF A KILLER 6.0/10 10分 U.L.Paperから写メが送られてくるのでチェック。パトカーを盗んでコンピューターにアクセス。顔写真での照合をすると現場までの案内が出る。現場に向かって、その場の敵を全員殺せばクリア。スナイパーライフルがある場合、道路を挟んだ南側にある建物の屋上から狙撃すると楽勝。非常ハシゴを登る為にクルマが必要になる。 DUST OFF 車に乗って目的地に行くとヘリの追跡が始まる。追跡は道をまっすぐ進むだけで大丈夫。ヘリを奪うときは、泳いでヘリポートに行くと敵と戦わずにすむ。ヘリポートには中央から登れる。(手間取ってると離陸して失敗になる。)後は空港に行けば終了。せっかくなので、ヘリのフライトを楽しむのもよいだろう。 PAPER TRAIL ヘリに乗ってターゲットのヘリを追跡する。ある程度追うと味方がRPGで撃墜しようとするので、ターゲットと高度・進路を合わせて飛ぶ。撃墜したら、目的地で味方をおろして終了。「右側に近づけ」と指示されるが、右後ろから一定距離を保てばOK。
https://w.atwiki.jp/metalmetabo/pages/16.html
Chemical genomics - visitors 2010 Propranolol and the risk of hospitalized myopathy Translating chemical genomics findings into population-level hypotheses S Setoguchi, JM Higgins, H Mogun, VK Mootha, J … - American Heart …, 2010 - Elsevier http //linkinghub.elsevier.com/retrieve/pii/S0002870309009624 New users of propranolol and other β-blockers (BBs) aged ≥65 were identified using data from Medicare and drug benefit programs in 2 states (1994-2005). The primary end point studied was hospitalization for myopathy or rhabdomyolysis. We used stratified Cox proportional ... Identification of an ABCB/P-glycoprotein-specific inhibitor of auxin transport by chemical genomics JY Kim, S Henrichs, A Bailly, V Vincenzetti, V … - Journal of Biological …, 2010 - ASBMB http //www.jbc.org/content/early/2010/05/14/jbc.M110.105981.full.pdf From the Laboratory of Plant Systems Bio-Dynamics, Pohang University of Science Technology, Pohang, Republic of Korea1,University of Zurich and Zurich-Basel Plant Science Center, Institute of Plant Biology, Zurich, Switzerland2, Department of Horticulture, ... Physcion-8-O-β-D-glucopyranoside enhances the commitment of mouse mesenchymal progenitors into osteoblasts and their differentiation Possible involvement of … SU Lee, YH Choi, YS Kim, SJ Park, HB … - Journal of Cellular …, 2010 - interscience.wiley.com ... 1 Laboratory of Chemical Genomics, Korea Research Institute of Chemical Technology, Daejeon 305-600, Korea 2 Department of Biology, Chungnam National University, Daejeon 305-765, Korea 3 Laboratory of Phytochemistry Research, Korea Research Institute of Chemical ... Preparation and characterization of monodisperse CdS quantum dot-polymer microspheres Q Shao, C Yang, L Jiang, J He, S … - Journal of Polymer …, 2010 - interscience.wiley.com ... 1 Nano-Micro Materials Research Center, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China 2 Shenzhen Key Laboratory of Special Functional Materials, Shenzhen ... Chemogenomic Profiling Provides Insights into the Limited Activity of Irreversible EGFR Inhibitors in Tumor Cells Expressing the T790M EGFR Resistance Mutation ML Sos, HB Rode, S Heynck, M Peifer, F Fischer, S … - Cancer Research, 2010 - AACR ... Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Köln, 2 Center of Integrated Oncology and Department I of Internal Medicine, University of Köln, Cologne, Germany; 3 Chemical Genomics Centre of the Max ... Inside Cover A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety (ChemMedChem 5/2010) MB Boxer, AM Quinn, M Shen, A Jadhav, W … - …, 2010 - interscience.wiley.com ... National Institutes of Health, National Human Genome Research Institute, NIH Chemical Genomics Center, 9800 Medical Center Drive, Rockville, Maryland 20850 (USA), Fax (+1) 301-217-5736. email Craig J. Thomas (craigt@mail.nih.gov). ... A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety MB Boxer, AM Quinn, M Shen, A Jadhav, W … - …, 2010 - interscience.wiley.com ... National Institutes of Health, National Human Genome Research Institute, NIH Chemical Genomics Center, 9800 Medical Center Drive, Rockville, Maryland 20850 (USA), Fax (+1) 301-217-5736. email Craig J. Thomas (craigt@mail.nih.gov). ... A Small Molecule Inverse Agonist for the Human Thyroid-Stimulating Hormone Receptor S Neumann, W Huang, E Eliseeva, S Titus, CJ … - Endocrinology, 2010 - Endocrine Soc ... Clinical Endocrinology Branch (SN, EE, MCG), National Institute of Diabetes and Digestive and Kidney Diseases, and National Institutes of Health (NIH) Chemical Genomics Center (WH, ST, CJT), National Human Genome Research Institute, NIH, Bethesda, Maryland 20892 ... Assay, Preclinical, and Clinical Brick Walls and Opportunities for System Change Through GRANDRx S Terry, C Austin, J Inglese, D Meeker, … - Assay and drug …, 2010 - liebertonline.com ... Christopher Austin NIH Chemical Genomics Center (NCGC), National Human Genome Research Institute, NIH, Rockville, Maryland. James Inglese NIH Chemical Genomics Center (NCGC), National Human Genome Research Institute, NIH, Rockville, Maryland. ... A chemical screen for suppressors of the avrRpm1-RPM1-dependent hypersensitive cell death response in Arabidopsis thaliana M Serrano, DA Hubert, JL Dangl, P Schulze-Lefert, E … - Planta, 2010 - Springer Page 1. ORIGINAL ARTICLE A chemical screen for suppressors of the avrRpm1-RPM1-dependent hypersensitive cell death response in Arabidopsis thaliana Mario Serrano • David A. Hubert • Jeffery L. Dangl • Paul Schulze-Lefert • Erich Kombrink ...
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《Paper Tiger》 #whisper じゃんけんサイクルである3体のクリーチャーの一つ。 このクリーチャーは「紙」なので、「岩」であるRock Lobsterに勝ち、「ハサミ」であるScissors Lizardに負ける。 紙といっても、戦力にならないカードではないので注意。 ルール・テキストにカード名を表記する場合、自身を指すのでない限りは「〜という名前のクリーチャー」とするのが標準であるが、銀枠であるせいかこの規則には則っていない。 フレイバー・テキスト (日本語訳は あんかば カードリストより引用) The tiger is always quick to fold. この虎はいつでも早く折り上がる。 なかなかしゃれたフレイバー・テキストである。 "paper tiger" は、日本語で言う「張子の虎」という意味である。 一方 "fold" が自動詞として使われる場合は、「(ぺしゃんこに)潰れる」というような意味になる。 つまり、このフレイバーはダブル・ミーニングである。 参考 カード個別評価:Unglued系
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Paper Feed VIP drawballスレの住人、王蟲の人作の殿堂入り作品にdrawball管理人が付けた名前
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Papaya "Papaya Leaf" The humble papaya is gaining credibility in Western medicine for anticancer powers that folk cultures have recognized for generations. University of Florida researcher and a professor of medicine Nam Dang, M.D., Ph.D., and colleagues in Japan have documented papaya’s dramatic anticancer effect against a broad range of lab-grown tumors, including cancers of the cervix, breast, liver, lung and pancreas. The researchers used an extract made from dried papaya leaves, and the anticancer effects were stronger when cells received larger doses of the tea. In a paper published in the Feb. 17 issue of the Journal of Ethnopharmacology, Dang and his colleagues also documented for the first time that papaya leaf extract boosts the production of key signaling molecules called Th1-type cytokines. This regulation of the immune system, in addition to papaya’s direct antitumor effect on various cancers, suggests possible therapeutic strategies that use the immune system to fight cancers. Nam Dang, M.D., Ph.D., a professor of medicine and medical director of the UF Shands Cancer Center Clinical Trials Office. The papaya extract did not have any toxic effects on normal cells, avoiding a common and devastating consequence of many cancer therapy regimens. The success of the papaya extract in acting on cancer without toxicity is consistent with reports from indigenous populations in Australia and his native Vietnam, said Dang, who is also medical director of the UF Shands Cancer Center Clinical Trials Office. “Based on what I have seen and heard in a clinical setting, nobody who takes this extract experiences demonstrable toxicity; it seems like you could take it for a long time — as long as it is effective,” he said. Researchers exposed 10 different types of cancer cell cultures to four strengths of papaya leaf extract and measured the effect after 24 hours. Papaya slowed the growth of tumors in all the cultures. To identify the mechanism by which papaya checked the growth of the cultures, the team focused on a cell line for T lymphoma. Their results suggested that at least one of the mechanisms employed by the papaya extract is inducing cell death. In a similar analysis, the team also looked at the effect of papaya extract on the production of antitumor molecules known as cytokines. Papaya was shown to promote the production of Th1-type cytokines, important in the regulation of the immune system. For that reason, the study findings raise the possibility of future use of papaya extract components in immune-related conditions such as inflammation, autoimmune disease and some cancers. Bharat B. Aggarwal, Ph.D., a researcher at the University of Texas M.D. Anderson Cancer Center in Houston, already is so convinced of papaya’s restorative powers that he has a serving of the fruit every day. “We have always known that papaya has a lot of interesting things in there,” said Aggarwal, a professor in the center’s department of experimental therapeutics who was not involved in the UF research. Foremost among papaya’s health-promoting agents is papain, papaya’s signature enzyme, which is found in both the fruit and the leaves. “This paper has not gone too much into identifying the components responsible for the activity, which is just fine. I think that is a good beginning,” Aggarwal said. Aggarwal also noted that papaya extract’s success in reducing cancer in laboratory cell cultures must next be replicated in animal and human studies. “I hope Dr. Dang takes it further, because I think we need enthusiastic people like him to move it forward,” Aggarwal said. Dang and a colleague have applied to patent the process to distill the papaya extract through the University of Tokyo; the next step in the research is to identify the specific compounds in the papaya extract active against the cancer cell lines. For this stage, Dang has partnered with Hendrik Luesch, Ph.D., a fellow UF Shands Cancer Center member and a professor of medicinal chemistry. Luesch is an expert in the identification and synthesis of natural products for medicinal purposes, and recently discovered a coral reef compound that inhibits cancer cell growth in cell lines.
https://w.atwiki.jp/metalmetabo/pages/20.html
- visitors Sulfurtransferases 2010 Cell Biology of Molybdenum F Bittner, RR Mendel - Cell Biology of Metals and Nutrients, 2010 - Springer http //scholar.google.co.jp/scholar?q=related 1fBydctAk0cJ scholar.google.com/ hl=ja as_sdt=2000 Abstract The transition element molybdenum (Mo) is essential for (nearly) all biological systems as it is required by enzymes catalyzing diverse key reactions in the global carbon, sulfur,and nitrogen metabolism. The metal itself is biologically inactive unless it is complexed by a ... 2009 Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions nih.gov [HTML]A Noma, Y Sakaguchi, T Suzuki - Nucleic Acids Research, 2009 - Oxford Univ Press http //scholar.google.co.jp/scholar?q=related kS8aGPMvT5kJ scholar.google.com/ hl=ja as_sdt=2000 The wobble modification in tRNAs, 5-methoxycarbonylmethyl-2-thiouridine (mcm 5 s 2 U), is required for the proper decoding of NNR codons in eukaryotes. The 2-thio group confers conformational rigidity of mcm 5 s 2 U by largely fixing the C3 -endo ribose puckering, ensuring stable ... Origin and function of ubiquitin-like proteins nih.gov [HTML]M Hochstrasser - Nature, 2009 - nature.com http //scholar.google.co.jp/scholar?q=related vqhk3w9krT0J scholar.google.com/ hl=ja as_sdt=2000 Eukaryotic proteins can be modified through attachment to various small molecules and proteins. One such modification is conjugation to ubiquitin and ubiquitin-like proteins (UBLs), which controls an enormous range of physiological processes. Bound UBLs ... 2008 Molybdoproteomes and evolution of molybdenum utilization nih.gov [HTML]Y Zhang, VN Gladyshev - Journal of molecular biology, 2008 - Elsevier http //scholar.google.co.jp/scholar?q=related g2yHxFnhe4AJ scholar.google.com/ hl=ja as_sdt=2000 as_ylo=1981 as_yhi=2010 The trace element molybdenum (Mo) is utilized in many life forms, and it is a key component of several enzymes involved in nitrogen, sulfur, and carbon metabolism. With the exception of nitrogenase, Mo is bound in proteins to a pterin, thus forming the molybdenum cofactor ( ... Common thiolation mechanism in the biosynthesis of tRNA thiouridine and sulphur-containing cofactors nih.gov [HTML]N Shigi, Y Sakaguchi, S Asai, T Suzuki, K … - The EMBO Journal, 2008 - nature.com http //scholar.google.co.jp/scholar?q=related ARSfgx3Fp70J scholar.google.com/ hl=ja as_sdt=2000 as_ylo=2001 as_yhi=2010 2-Thioribothymidine (s 2 T), a modified uridine, is found at position 54 in transfer RNAs (tRNAs) from several thermophiles; s 2 T stabilizes the L-shaped structure of tRNA and is essential for growth at higher temperatures. Here, we identified an ATPase (tRNA-two-thiouridine ... The Sulfurtransferase Activity of Uba4 Presents a Link between Ubiquitin-like Protein Conjugation and Activation of Sulfur Carrier Proteins† J Schmitz, MM Chowdhury, P Hänzelmann, M … - Biochemistry, 2008 - ACS Publications http //scholar.google.co.jp/scholar?q=related tu5O65itnDEJ scholar.google.com/ hl=ja as_sdt=2000 as_ylo=2001 as_yhi=2010 Because of mechanistic parallels in the activation of ubiquitin and the biosynthesis of several sulfur-containing cofactors, we have characterized the human Urm1 and Saccharomyces cerevisiae Uba4 proteins, which are very similar in sequence to MOCS2A and MOCS3, respectively, ... Thio-modification of yeast cytosolic tRNA requires a ubiquitin-related system that resembles bacterial sulfur transfer systems jbc.org [HTML]Y Nakai, M Nakai, H Hayashi - Journal of Biological Chemistry, 2008 - ASBMB http //scholar.google.co.jp/scholar?q=related rEPGgeDDU4AJ scholar.google.com/ hl=ja as_sdt=2000 The wobble uridine in yeast cytosolic tRNA Lys2 UUU and tRNA Glu3 UUC undergoes a thio-modification at the second position (s 2 modification) and a methoxycarbonylmethyl modification at the fifth position (mcm 5 modification). We previously demonstrated that the cytosolic ... An embarrassment of riches the enzymology of RNA modification nih.gov [HTML]D Iwata-Reuyl - Current opinion in chemical biology, 2008 - Elsevier http //scholar.google.co.jp/scholar?q=related 0tsj3spLBLEJ scholar.google.com/ hl=ja as_sdt=2000 The maturation of transfer RNA (tRNA) involves extensive chemical modification of the constituent nucleosides and results in the introduction of significant chemical diversity to tRNA. Many of the pathways to these modified nucleosides are characterized by chemically complex ... A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae cshlp.org [HTML]B Huang, J Lu, AS Byström - Rna, 2008 - rnajournal.cshlp.org http //scholar.google.co.jp/scholar?q=related 4xQVocA9SD4J scholar.google.com/ hl=ja as_sdt=2000 We recently showed that the γ-subunit of Kluyveromyces lactis killer toxin (γ-toxin) is a tRNA endonuclease that cleaves , , and 3′ of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine (mcm 5 s 2 U). The 5-methoxycarbonylmethyl ... 2007 Biosynthesis of the Thio-quinolobactin Siderophore an Interesting Variation on Sulfur Transfer nih.gov [HTML]AM Godert, M Jin, FW McLafferty, TP … - Journal of …, 2007 - Am Soc Microbiol http //scholar.google.co.jp/scholar?q=related EBTZm24E50AJ scholar.google.com/ hl=ja as_sdt=2000 Text 15 Thio-quinolobactin, 8-hydroxy-4-methoxy-thioquinaldic acid (structure 1), is a 16 ... 17400.(10-12) The genes responsible for the biosynthesis of thio-quinolobactin have 18 ... There are a number of naturally occurring molecules of diverse structure that 27 A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast cshlp.org [HTML]GR Björk, B Huang, OP Persson, AS Byström - Rna, 2007 - rnajournal.cshlp.org http //scholar.google.co.jp/scholar?q=related ufP8yaCqiVsJ scholar.google.com/ hl=ja as_sdt=2000 Transfer RNAs specific for Gln, Lys, and Glu from all organisms (except Mycoplasma) and organelles have a 2-thiouridine derivative (xm 5 s 2 U) as wobble nucleoside. These tRNAs read the A- and G-ending codons in the split codon boxes His/Gln, Asn/Lys, and Asp/Glu. In ... 2006 Crystal structure of Bacillus anthracis ThiI, a tRNA-modifying enzyme containing the predicted RNA-binding THUMP domain DG Waterman, M Ortiz-Lombardía, MJ Fogg, EV … - Journal of molecular …, 2006 - Elsevier http //scholar.google.co.jp/scholar?q=related j-_C2YkFA-IJ scholar.google.com/ hl=ja as_sdt=2000 as_ylo=1981 as_yhi=2010 ThiI is an enzyme responsible for the formation of the modified base S 4 U (4-thiouridine) found at position 8 in some prokaryotic tRNAs. This base acts as a sensitive trigger for the response mechanism to UV exposure, providing protection against its damaging effects. We ... Trafficking in persulfides delivering sulfur in biosynthetic pathways EG Mueller - Nature Chemical Biology, 2006 - nature.com http //scholar.google.co.jp/scholar?q=related ZzZgR5SebvcJ scholar.google.com/ hl=ja as_sdt=2000 The presence of sulfur in cofactors has been appreciated for over a century, but the trafficking and delivery of sulfur to cofactors and nucleosides is still not fully understood. In the last decade, great strides have been made toward understanding those processes and the ... Cell biology of molybdenum RR Mendel, F Bittner - Biochimica et Biophysica Acta (BBA)-Molecular …, 2006 - Elsevier http //scholar.google.co.jp/scholar?q=related C6ckangyps8J scholar.google.com/ hl=ja as_sdt=2000 The transition element molybdenum (Mo) is of essential importance for (nearly) all biological systems as it is required by enzymes catalyzing diverse key reactions in the global carbon, sulfur and nitrogen metabolism. The metal itself is biologically inactive unless it is complexed by ... The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like β-grasp domains biomedcentral.com [HTML]LM Iyer, AM Burroughs, L Aravind - Genome Biology, 2006 - biomedcentral.com http //scholar.google.co.jp/scholar?q=related UgYKXG9Yy80J scholar.google.com/ hl=ja as_sdt=2000 Ubiquitin (Ub)-mediated signaling is one of the hallmarks of all eukaryotes. Prokaryotic homologs of Ub (ThiS and MoaD) and E1 ligases have been studied in relation to sulfur incorporation reactions in thiamine and molybdenum/tungsten cofactor biosynthesis. However, there is no ... Mechanistic insights into sulfur relay by multiple sulfur mediators involved in thiouridine biosynthesis at tRNA wobble positions cell.com [HTML]Y Ikeuchi, N Shigi, J Kato, A Nishimura, T Suzuki - Molecular cell, 2006 - Elsevier http //scholar.google.co.jp/scholar?q=related 2Vsoqag0uDsJ scholar.google.com/ hl=ja as_sdt=2000 The wobble bases of bacterial tRNAs responsible for NNR codons are modified to 5-methylaminomethyl-2-thiouridine (mnm 5 s 2 U). 2-thio modification of mnm 5 s 2 U is required for accurate decoding and essential for normal cell growth. We identified five genes yhhP, ... 2005 Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs implications for the molecular … jbc.org [HTML]N Umeda, T Suzuki, M Yukawa, Y Ohya, H … - Journal of Biological …, 2005 - ASBMB http //scholar.google.co.jp/scholar?q=related l9eGdubEKOEJ scholar.google.com/ hl=ja as_sdt=2000 as_ylo=1981 as_yhi=2010 Human mitochondrial (mt) tRNA Lys has a taurine-containing modified uridine, 5-taurinomethyl-2-thiouridine ( m 5 s 2 U), at its anticodon wobble position. We previously found that the mt tRNA Lys , carrying the A8344G mutation from cells of patients with myoclonus ... l-Cysteine Desulfidase An [4Fe-4S] Enzyme Isolated from Methanocaldococcus jannaschii That Catalyzes the Breakdown of l-Cysteine into Pyruvate, Ammonia, and … SI Tchong, H Xu, RH White - Biochemistry, 2005 - ACS Publications http //scholar.google.co.jp/scholar?q=related QUO6D5wSaMQJ scholar.google.com/ hl=ja as_sdt=2000 as_ylo=1981 as_yhi=2010 A [4Fe-4S] enzyme that decomposes l-cysteine to hydrogen sulfide, ammonia, and pyruvate has been isolated and characterized from Methanocaldococcus jannaschii. The sequence of the isolated enzyme demonstrated that the protein was the product of the M. jannaschii ... Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis nih.gov [HTML]KE Burns, S Baumgart, PC Dorrestein, H Zhai, … - J. Am. Chem. …, 2005 - ACS Publications http //scholar.google.co.jp/scholar?q=related 6UxhZ1K_8BAJ scholar.google.com/ hl=ja as_sdt=2000 A new pathway for cysteine biosynthesis has been elucidated in Mycobacterium tuberculosis. This pathway involves a protein-bound thiocarboxylate (CysO−SH) as the sulfide donor, similar to thiamin biosynthesis. Cysteine synthase M (CysM) catalyzes the addition ... 2004 Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans pnas.org [HTML]A Matthies, KV Rajagopalan, RR … - Proceedings of the …, 2004 - National Acad Sciences http //scholar.google.co.jp/scholar?q=related PpXEO3soBo0J scholar.google.com/ hl=ja as_sdt=2000 Recent studies have identified the human genes involved in the biosynthesis of the molybdenum cofactor. The human MOCS3 protein contains an N-terminal domain similar to the Escherichia coli MoeB protein and a C-terminal segment displaying similarities to the ... Ubiquitin-proteasome system umaryland.edu [PDF]S Fang, AM Weissman - Cellular and molecular life sciences, 2004 - Springer http //scholar.google.co.jp/scholar?q=related UwB61_LeFJAJ scholar.google.com/ hl=ja as_sdt=2000 Abstract. The capacity for exquisite regulation of ubiq- uitylation provides eukaryotic cells with a means to fine- tune both protein function and levels. This complex set of processes affects myriad proteins and potentially impacts all cellular processes. Ubiquitylation is brought about ... 2003 Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1p nih.gov [HTML]AS Goehring, DM Rivers, GF Sprague Jr - Eukaryotic cell, 2003 - Am Soc Microbiol http //scholar.google.co.jp/scholar?q=related NuIwzhoOL5cJ scholar.google.com/ hl=ja as_sdt=2000 Urm1p is a ubiquitin-related protein that serves as a posttranslational modification of other proteins. Urm1p conjugation has been implicated in the budding process and in nutrient sensing. Here, we have identified the first in vivo target for the urmylation pathway as the ... 2002 The rhodanese/Cdc25 phosphatase superfamily nih.gov [HTML]D Bordo, P Bork - EMBO reports, 2002 - nature.com http //scholar.google.co.jp/scholar?q=related OxriJBcqB5AJ scholar.google.com/ hl=ja as_sdt=2000 ... In this review, the rhodanese/Cdc25 phosphatase superfamily is analyzed. ... Figure 3 Neighbor-joining tree representing the rhodanese superfamily generated by CLUSTALW (correction for ... Catalytically active rhodanese and Cdc25 phosphatase domains The N- and C- ... 2001 A sulfurtransferase is required in the transfer of cysteine sulfur in the in vitro synthesis of molybdopterin from precursor Z in Escherichia coli jbc.org [HTML]S Leimkühler, KV Rajagopalan - Journal of Biological Chemistry, 2001 - ASBMB http //scholar.google.co.jp/scholar?q=related q8ya_wsSejkJ scholar.google.com/ hl=ja as_sdt=2000 It has been shown that conversion of precursor Z to molybdopterin (MPT) by Escherichia coli MPT synthase entails the transfer of the sulfur atom of the C-terminal thiocarboxylate from the small subunit of the synthase to generate the dithiolene group of MPT and that the moeB ... M ECHANISMS U NDERLYING U BIQUITINATION uky.edu [PDF]CM Pickart - Annual review of biochemistry, 2001 - Annual Reviews http //scholar.google.co.jp/scholar?q=related YIxzrFekkFQJ scholar.google.com/ hl=ja as_sdt=2000 as_ylo=2001 as_yhi=2001 Abstract The conjugation of ubiquitin to other cellular proteins regulates a broad range of eukaryotic cell functions. The high efficiency and exquisite selectivity of ubiquitination reactions reflect the properties of enzymes known as ubiquitin-protein ligases or E3s. An E3 recognizes its ... 2000 Evolution and function of ubiquitin-like protein-conjugation systems yale.edu [PDF]M Hochstrasser - Nature cell biology, 2000 - nature.com http //scholar.google.co.jp/scholar?q=related w2aIi7-UqxoJ scholar.google.com/ hl=ja as_sdt=2000 Cellular proteins are frequently adorned with chemical modifications that alter their physical — and, as a result, their physiological — properties. Among the most spectacular of these molecular appendages are grafts of other proteins or even polymeric chains of other proteins. The ... A protein conjugation system in yeast with homology to biosynthetic enzyme reaction of prokaryotes jbc.org [HTML]K Furukawa, N Mizushima, T Noda, Y … - Journal of Biological …, 2000 - ASBMB http //scholar.google.co.jp/scholar?q=related kWwdzGB67rIJ scholar.google.com/ hl=ja as_sdt=2000 Protein conjugation, such as ubiquitination, is the process by which the C-terminal glycine of a small modifier protein is covalently attached to target protein(s) through sequential reactions with an activating enzyme and conjugating enzymes. Here we report on a novel protein ... 1998 Cysteine Sulfinate Desulfinase, a NIFS-like Protein of Escherichia coli with Selenocysteine Lyase and Cysteine Desulfurase Activities Gene Cloning, Purification and … kyoto-u.ac.jp [PDF]N Esaki, T Kurihara, T Yoshimura, K … - ICR annual …, 1998 - repository.kulib.kyoto-u.ac.jp http //scholar.google.co.jp/scholar?q=related QtLum1tHQrQJ scholar.google.com/ hl=ja as_sdt=2000 Page 1. Kyoto University KURENAI Kyoto University Research Information Repository Title Cysteine Sulfinate Desulfinase, a NIFS-like Protein of Escherichia coli with Selenocysteine Lyase and Cysteine Desulfurase Activities ... 1997 Cysteine Sulfinate Desulfinase, a NIFS-like Protein ofEscherichia coli with Selenocysteine Lyase and Cysteine Desulfurase Activities jbc.org [HTML]H Mihara, T Kurihara, T Yoshimura, K Soda, N … - Journal of Biological …, 1997 - ASBMB http //scholar.google.co.jp/scholar?q=related bOaL5q7FBDoJ scholar.google.com/ hl=ja as_sdt=2000 Selenocysteine lyase (EC 4.4.1.16) exclusively decomposes selenocysteine to alanine and elemental selenium, whereas cysteine desulfurase (NIFS protein) of Azotobacter vinelandii acts indiscriminately on both cysteine and selenocysteine to produce elemental sulfur and selenium ... 1991 Characteristics of Nicotiana tabacum nitrate reductase protein produced in Saccharomyces cerevisiae. nih.gov [PDF]HN Truong, C Meyer, F Daniel-Vedele - Biochemical Journal, 1991 - ncbi.nlm.nih.gov http //scholar.google.co.jp/scholar?q=related 8oijnWbQUp4J scholar.google.com/ hl=ja as_sdt=2000 as_ylo=1981 as_yhi=2010 INTRODUCTION Tobacco nitrate reductase (NR) (EC 1.6.6.1) is a homodimeric enzyme that reduces nitrate to nitrite in the presence of NADH (NADH NR activity). Each of its subunits contains three domains carrying respectively the prosthetic groups FAD, haem (cytochrome b-557) ... UBA 1 an essential yeast gene encoding ubiquitin-activating enzyme. nih.gov [PDF]JP McGrath, S Jentsch, A Varshavsky - The EMBO journal, 1991 - ncbi.nlm.nih.gov http //scholar.google.co.jp/scholar?q=related qFlUGfxF0asJ scholar.google.com/ hl=ja as_sdt=2000 The EMBO Journal vol.10 no.1 pp.227-236, 1991 ... UBA 1 an essential yeast gene encoding ubiquitin- ... John P.McGrath, Stefan Jentsch and Alexander Varshavsky ... Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Present ...