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Loading Message Loading中に出てくる1行ヒント的なメッセージ。結局表示時間が短くて、読めないことがほとんどなわけだが。表示されている種類はこんな感じらしい。 GENERAL Press I to open your inventory. Press K to access your skill tree. Some items grant you skills while equipped. Personal Relocation Devices allow you to visit a station and then return to the battlefield. Items marked with a ? require an Analyzer to identify their properties. Battle Sets are mapped to F1, F2, and F3 and can hold different weapons and skills. You can pick up items by hitting F . Items such as Health Injectors and Powerpacks are consumed when you use them. So, stock up. Armor reduces the amount of damage received by an attack. Shields completely negate damage unless they are penetrated, knocked down, or overloaded. The Nano Forge is used to increase the basic power and level of items. The Augmentrex 3000 is used to add random enhancements to items. The Delux De-Modificator is used to remove mods from weapons. The six types of Mods are Fuel, Batteries, Ammo, Rockets, Techs, and Relics. Mods can only be removed from weapons by using the Delux De-Modificator found in most Stations. Mods of all sorts can be used to make your weapons more specialized or versatile. You can place items in a Storage Depot locker found in most Stations. Some environments have rare locations that you can find. Make sure you explore everywhere. Right-click and hold when selecting an NPC or Item to activate a radial menu with several fast-action options. NAVIGATION Press TAB to open the Mini-map. Press TAB again to expand the map to the center of your display. Press M to view the World Map. A purple question mark (?) on the Mini-map shows the location of a storyline quest. A yellow exclamation point (!) on the Mini-map shows the location of a side mission. A green British pound symbol (￡) on the Mini-map shows the location of a vendor. A red cross (+) on the Mini-map shows the location of a medic or healer. A blue X on the Mini-map shows the location of an open portal, passage or Hellrift. A red X on the Mini-map shows the location of a closed portal, passage or Hellrift. To zoom in on the Mini-map, press the + symbol on the map. STAT FEED ADVICE Higher Strength will allow you to equip heavier armor. Higher Accuracy will allow you to equip more powerful guns. Higher Willpower will allow you to equip more powerful swords. Higher Willpower will allow you to equip more powerful weapon mods. Higher Willpower will allow you to equip more powerful focus items. Higher Stamina will allow you to equip better shields. Higher Willpower will allow you to equip some weapons and armor with more powerful attributes. Higher Stamina will allow you to equip some armor with more powerful attributes. SKILL POINTS STAT POINTS When you gain a level, you receive an additional skill point. You have skill points to spend. Press K to open your skill tree. When you gain a level, you earn 5 points to distribute amongst your attributes. You have attribute points to spend. Press I to open your inventory and attributes screen. SHIFT CONTROL KEYS When moving forward, pressing SHIFT will activate your Sprint skill. You can toggle whether a skill can be activated by SHIFT by checking it in your skill tree. The left side of the Action Bar shows which skill will be activated by SHIFT . The right side of the Action Bar shows which boost will be used by CONTROL . SECONDARY DAMAGE EFFECTS Phased monsters and characters deal half damage and take 50% more damage. When you re poisoned, you can t heal until the toxic effects are gone. "An ignited enemy loses 5% health per second." - Argus HIGH LEVEL CHARACTER ADVICE You should really know what you re doing by now. EVOKER ADVICE The Evoker s spell damage comes from his focus items and not the spells themselves. Almost all Evoker skills require a focus item. "Pick the proper skill for the moment." - Bogi "Two focus items means more damage." - Bogi "Higher damage focus items increase the damage of all Evoker spells." - Bogi Make sure that you use both long and short range spells. "Word of Fear is often your best protection." - Bogi "Use one Battle Set for damage and another for elemental attacks." - Bogi SUMMONER ADVICE "A Demon for every situation. . . choose carefully." - Ragthor Each Elemental that you control reduces your total available power. Meat Shield and Enrage are powerful commands for your Carnagor. "Receive every battle with an army." - Ragthor "When surrounded, use Word of Fear." - Ragthor "Select the perfect moment for the Reaper." - Ragthor "Use Blood Link to keep your minion alive." - Ragthor Pets can be dismissed by clicking on their portrait. BLADEMASTER ADVICE You can only have one Aura active at a time. "Do not lose heart in the heat of battle." - Adiss "Have a set of weapons ready for each opponent." - Adiss "Having more skills gives you more options." - Adiss "Call of the Chosen helps disperse crowds of enemies." - Adiss "Two swords are better than one." - Adiss "Sweeping Strike is very effective for packs of small enemies." - Adiss "Each enemy in your Holy Radius strengthens your Aura." - Adiss "Surges are gained by killing a monster with a surge skill." - Adiss "It is very powerful to have multiple surges." - Adiss GUARDIAN ADVICE "Have faith in your shield. It can stun almost any foe." - George You can only have one Aura active at a time. "If you live longer than your enemy, you win." - George "You can control a battle with patience and a strong shield." - George "Anchor, Challenge and Sword of Reckoning are a deadly combination." - George "Get surrounded - each enemy strengthens your Aura." - George "Spiritual Strength allows you to equip much more powerful armor." - George "Switch auras as you fight - each one has a different purpose." - George MARKSMAN ADVICE "Know when to stand and when to withdraw." - Argus The Tactical Stance, Rapid Fire, and Sniper skills require you to stop moving. Precision Strike and Grenade skills improve as your character gains levels. Use the Escape skill when you re surrounded or overwhelmed. Critical Hits can trigger skills - like Ricochet and Reflected Shot. "Create a Battle Set for close range and another for long range." - Argus "Keep upgrading your weapons." - Argus "Grenades work well with low rate of fire guns." - Argus ENGINEER ADVICE "Metal is cheap. Let them hit the Drone." - Johnny "You can control only two kinds of Bots at once." - Johnny Your Drone can be upgraded with a handgun, rifle, sword, and torso armor. "Drones feel no pain." - Johnny The Drone s armor and weapons are saved with your character. "Watch your Inhibitor Bots, and no one will sneak up on you." - Johnny "Nanobots are quite effective." - Johnny Bots cannot be targeted. SOCIAL Treat others with the respect you would expect from them. Joining groups increases the experience and rewards you earn! Joining a Guild is a great way to always have friends to adventure with. Using all caps when chatting is considered rude because YOU ARE YELLING! You only see the items you can pick up when in a group. If you can t use an item, you can usually sell it, trade it, or dismantle it for scrap. Make sure to put people you know or like playing with on your Buddy List! Press B to access your Buddy List. To add a friend to your Buddy List, just type the name of the character you want to include in the Buddy panel. Now you ll know when they are online! CHAT WINDOW To talk with other players in the game, simply press ` to activate the chat window. To speak privately with a specific player, open the chat window and type /w playername your message To speak to everyone in your immediate vicinity, open the chat window and type /town your message To speak with everyone in your adventuring party, open the chat window and type /p your message Your chat log will fade after a time, but you view it again by pressing the small arrow button located on the top left of your Health orb. MISCELLANEOUS Take everything in moderation, including Hellgate London! It s a good idea to stretch your hands and legs every 15 - 20 minutes. Remember to eat a healthy meal, drink plenty of water, and get enough sleep! If something is frustrating you, fire up some Hellgate London and have fun! 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https://w.atwiki.jp/mrfrtech/pages/69.html
Market Synopsis Market Research Future (MRFR) conducted study on the Identity as a Service Market Segments 2020 and detailed insights into the effect of COVID pandemic on the market in the report. According to MRFR analysis, the identity as a service (IDaaS) market can rise at 18.4% CAGR across the forecast period. By 2027, the identity as a service (IDaaS) market value can cross USD 10 Bn. The growing deployment of IDaaS on largely accepted cloud platform can boost the expansion of the IDaaS market across the review period. The increase in the adoption of SaaS-based IAM offerings that allow organizations to use single sign-on (SSO) via OpenID Connect (OIDC) or Security Assertion Markup Language (SAML) for the authentication and access controls to provide secured access to enterprises' SaaS applications can promote the expansion of the world market of IDaaS. The growing need to curb on-site infrastructure that can support a wide range of integration options can boost the expansion of the IDaaS market. The rise in the level of interconnectivity as IoT and BYOD culture are trending across different verticals can bolster the expansion of the IDaaS market. Rise in IDaaS vendors can also benefit the global market. The high utility of DevSecOps practices for the identification and access management in organizations can fuel the expansion of the market growth. The growing concerns of companies regarding data security limit is pressing the need for IDaaS solutions that can promote the expansion of the global identity as a service (IDaaS) market in the years to come. The rise in preference for on-premise access management systems can pose threat to the IDaaS market. Request a Free Sample @ https //www.marketresearchfuture.com/sample_request/7928 Market Segmentation The segments study of the global IDaaS market is based on deployment, service, organization size, and vertical. The service-based, the global IDaaS market segments are access, identity governance administration, and intelligence. The organization size based, the global IDaaS market segments are large enterprise and small- and medium-sized enterprise (SME). The deployment based, the global IDaaS market segments are public cloud, private cloud, and hybrid. The vertical based, the global IDaaS market segments are BFSI, retail and CPG, manufacturing, energy and utilities, transportation, healthcare and life sciences, and government and defense among others. Regional Analysis North America IDaaS market is expected to secure the highest global market size in the forecast period. Led by the US, the market in North America can rise exponentially due to the early adoption of DevSecOps that aids in the identification and allows access to management and strict government directives associated with data protection. The increase in cyber threats and high growing demand for potential and powerful authentication solutions on cloud can drive the IDaaS market in North America. In Asia Pacific, the IDaaS market can expand rapidly in evaluation period. The growing BYOD trend and increase in IoT applications across verticals and increase in the awareness among enterprises regarding security issues can promote the IDaaS market in the Asia Pacific region. APAC is observed to hold high growth prospects, thus the expansion of the IDaaS market in the Asia Pacific region is expected to rise substantially. Key Players MRFR identified some notable players of the global IDaaS market. They are; Okta, Inc. (US), Avatier (US), OneLogin, Inc (US), Fischer Identity (US), Microsoft Corporation, (US), Oracle Corporation (US), Centrify Corporation (US), Ping Identity (US), iWelcome (Netherlands), empowerID (US),VMWare (US), LoginRadius (Canada), IDaptive, LLC. (US), Ubisecure, Inc. (Finland), Sailpoint (US), Optimal IdM(US), Bitium, Inc. (US), and others. These players are recognized by origin, regional presence, recent key innovations, industry expertise, and product diversification. Access Report Details @ https //www.marketresearchfuture.com/reports/identity-service-market-7928 Table of Contents 1 Executive Summary 2 Scope of The Report 2.1 Market Definition 2.2 Scope of The Study 2.2.1 Research Objectives 2.2.2 Assumptions Limitations 2.3 Markets Structure 3 Market Research Methodology 3.1 Research Process 3.2 Secondary Research 3.3 Primary Research 3.4 Forecast Model Continued… Similar Report B2B Telecommunication Market Forensic Accounting Market Trending #MRFR Report** https //ictmrfr.blogspot.com/2022/04/geofencing-market-companies-growth-with.html https //blogfreely.net/pranali004/telecom-expense-management-market-size-impressive-cagr-changing-business-scope https //postheaven.net/pranali004/financial-app-industry-impressive-cagr-changing-business-needs-scope-of https //market-research-future.tribe.so/post/openstack-service-market-research-impressive-cagr-changing-scope-of-current--6263de46791566c10c79891e https //www.scutify.com/articles/2022-04-24-infrastructure-as-a-service-industry-cagr-changing-business-scope-of-current-and-future-industry- About Market Research Future At Market Research Future (MRFR), we enable our customers to unravel the complexity of various industries through our Cooked Research Report (CRR), Half-Cooked Research Reports (HCRR), Raw Research Reports (3R), Continuous-Feed Research (CFR), and Market Research Consulting Services. Contact Market Research Future (Part of Wantstats Research and Media Private Limited) 99 Hudson Street, 5Th Floor New York, NY 10013 United States of America 1 628 258 0071 (US) 44 2035 002 764 (UK) Email sales@marketresearchfuture.com Website https //www.marketresearchfuture.com
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rubyでのメタプログラミングのヘルパ集 rubywaves で使っているAutoCodeがrequireしている。 http //whytheluckystiff.net/articles/seeingMetaclassesClearly.html Dwemthy の Array ：http //poignantguide.net/dwemthy/ (http //poignantguide.net/ruby/index.html) (http //www.aoky.net/articles/why_poignant_guide_to_ruby/index.html) Sunday, April 17, 2005 Seeing Metaclasses Clearly If you’re new to metaprogramming in Ruby and you’d like to start using it, perhaps these four methods could give you a bit more vision. class Object # The hidden singleton lurks behind everyone def metaclass; class self; self; end; end def meta_eval blk; metaclass.instance_eval blk; end # Adds methods to a metaclass def meta_def name, blk meta_eval { define_method name, blk } end # Defines an instance method within a class def class_def name, blk class_eval { define_method name, blk } end end I’ve been keeping these methods in a file called metaid.rb and it’s a start toward building a little library that can simplify use of metaclasses. Let’s talk about metaclasses and I advise you to keep metaid.rb at your side. Take time to run some code from this article and you’ll understand much better. About Classes Well, what is a Class? Let’s create a simple object and see. class MailTruck attr_accessor driver, route def initialize( driver, route ) @driver, @route = driver, route end end m = MailTruck.new( Harold , [ 12 Corrigan Way , 23 Antler Ave ] ) = # MailTruck 0x81cfb94 @route=[ 12 Corrigan Way , 23 Antler Ave ], @driver= Harold m.class = MailTruck An Object is storage for variables. Instance variables. A MailTruck object, once initialized, will have a @driver and a @route variable. It can hold any other variables as well. m.instance_variable_set( @speed , 45 ) = 45 m.driver = Harold Okay, so the @driver instance variable has an accessor. When Ruby sees attr_accessor driver in the MailTruck class definition, you get reader and writer methods. The methods driver and driver=. These methods are stored in the class. So the instance variable is in the object and the accessor methods are in the class. They’re in two completely different spots. It’s an important lesson objects do not store methods, only classes can. Classes Are Objects Okay, but classes are objects, right? I mean if everything is an object in Ruby, then classes and objects should both be objects. Which makes them the same? Sure, classes are objects. You can run all the same methods on classes that you can run on object. Look, they each have their own ID in the symbol table. m.object_id = 68058570 MailTruck.object_id = 68069450 But I’ve already told you classes store methods. They’re different. Now I know you’re probably a bit confused wondering, “If a class is an object, but objects are built on classes, isn’t there a big confusing infinite cycle here that you’re not explaining?” No, there’s not. I hate to break it to you, but a class isn’t really an object. From Ruby’s source code struct RObject { struct RBasic basic; struct st_table *iv_tbl; }; struct RClass { struct RBasic basic; struct st_table *iv_tbl; struct st_table *m_tbl; VALUE super; }; Look! A class has an m_tbl (a symbol table for storing methods) and a superclass (pointer to a superclass). But let me reassure you. To a Ruby programmer, a class is an object. Because it meets the two big criteria you can store instance variables in a class and it is descended from the Object class. That’s it. o = Object.new = # Object 0x815c45c o.class = Object Class.superclass.superclass = Object Object.class = Class Object.superclass = nil The Object class sits at the very head of the table and comes down to participate only when it has methods that can’t be found anywhere else. What On Earth Are Metaclasses? The term metaclass is supposed mean “a class which defines classes.” This definition doesn’t really work with Ruby, though, since “a class which defines a class” is simply a Class. Look at how you can add a method in the Class class and then use it in class definitions. class Class def attr_abort( *args ) abort Please no more attributes today. end end class MyNewClass attr_abort id, diagram, telegram end Which prints Please no more attributes today. The attr_abort method can be used in definitions. You’re constantly defining and redefining classes in Ruby. It’s not meta, it’s just part of the code. Classes hold methods. How can you complicate that? Since the earlier definition doesn’t really work, I like to think of the Ruby metaclass as “a class which an object uses to redefine itself.” Do Objects Need Metaclasses? Objects can’t hold methods. Most objects don’t need to hold methods. But sometimes you may want an object to have some methods. Sometimes that’s your answer to a problem. You can’t do that. But Matz has given us metaclasses which are good enough. In the YAML library, you can customize the properties shown when an object is output. require yaml class m def to_yaml_properties [ @driver , @route ] end end YAML dump m --- !ruby/object MailTruck driver Harold route - 12 Corrigan Way - 23 Antler Ave This is handy if you want to dump one specific object with a certain style of YAML without effecting every object from that class. In the above example, only the object in the m variable will be output with its properties in order. All other MailTruck objects will be output in whatever way the YAML library chooses. Sometimes we may want to display a certain string one way without needing to modify the String class (which affects every string in your code). So the object in the m variable has its own special to_yaml_properties method. It’s stored in a metaclass. The metaclass stores methods for the object and sits right in the inheritance chain. We could also add the to_yaml_properties method with this convenient syntax def m.to_yaml_properties [ @driver , @route ] end If you have the metaid.rb methods from the top of this article loaded, try this m.metaclass = # Class # MailTruck 0x81cfb94 m.metaclass.class = Class m.metaclass.superclass = # Class MailTruck m.metaclass.instance_methods = [..., to_yaml_properties , ...] m.singleton_methods = [ to_yaml_properties ] When you use the class m syntax, you’re opening up a metaclass. Ruby calls these virtual classes. Notice the result of m.metaclass. A class attached to an object # Class # MailTruck 0x81cfb94 . When an object finds methods in an attached metaclass, these methods are referred to as the object’s singleton methods rather than the object’s metaclass’ instance methods (if you get my drift.) And since there can only be a single metaclass attached to an object, it’s called a _single_ton. It’s much easier to see metaclasses when you’re using the metaclass method. Normally, you would need to use ( class self; self; end ) wherever you wanted to root out a metaclass. But this makes it much simpler. Do Metaclasses Need Metaclasses? m.metaclass.metaclass = # Class # Class # MailTruck 0x81cfb94 m.metaclass.metaclass.metaclass = # Class # Class # Class # MailTruck 0x81cfb94 Check out those frivolous metaclasses we’re creating. So what can we do with a metaclass of a metaclass? Well, the same thing we do with a normal metaclass. A normal metaclass holds methods for an object. So a metaclass of a metaclass holds methods for that metaclass—which is just an object, of course! The problem with a metaclass of a metaclass is that there’s not much practical use for them. You can only use the methods if you’re deep inside the chain and we don’t really want to spend much time down there. m.meta_eval do self.meta_eval do self.meta_eval do def ribbit; *ribbit* ; end end end end m.metaclass.metaclass.metaclass.singleton_methods = [ class_def , metaclass , constants , meta_def , attr_test , nesting , ribbit ] Metaclasses are only really useful one level deep. You want to have give methods to an object. Or, as you will see, you might want a specific class to have a metaclass. Beyond that, you’re just storing methods in these obscure metaclasses that no one can really get at. Which you might need to do sometime. Who knows. The important thing to know at this point is metaclasses don’t go up, they go out. Yes, when you create a metaclass for an object, it happens to intercept method calls before the object’s inheritance chain. But that doesn’t mean inheritance is affected by further metaclasses. When you create a metaclass of a metaclass, it has no affect on the object referred to by the original metaclass. Metaclasses Have One More Funky Trick For Classes and It’s The Crucial Trick In The Metaprogrammer’s Handbook One more point and I believe this one is the juiciest. If you read the rest of this essay and quit before this section, you’ve come away without the most important lesson. You may know some nice things about objects and metaclasses, but it all pales. I’m going to reiterate two previous statements about classes and build on them. Class are objects. This means they can hold instance variables. Metaclasses hold instance methods. When attached to an object, these methods become singleton methods. These methods intercept calls before they trickle up the chain of inheritance. Have you ever used instance variables in a class before? I don’t mean in a class method. I mean in the class itself. class MailTruck @trucks = [] def MailTruck.add( truck ) @trucks truck end end Why not just use a class variable? class MailTruck @@trucks = [] def MailTruck.add( truck ) @@trucks truck end end They work exactly the same, right? I mean it doesn’t matter, does it? Here are two reasons you’ve probably been using class variables rather than class instance variables Class variables are clearly class variables. They have two at-symbols. Less confusion. Class variables can be referenced in instance methods, if needed. See, this works properly class MailTruck @@trucks = [] def MailTruck.add( truck ) @@trucks truck end def say_hi puts Hi, I m one of #{@@trucks.length} trucks! end end But this does not class MailTruck @trucks = [] def MailTruck.add( truck ) @trucks truck end def say_hi puts Hi, I m one of #{@trucks.length} trucks! end end So what are instance variables good for? What a waste of space! I’m never using them again! (Yes, please stick to class variables in situations like the above.) Let me also point out that metaclasses are again showing up above, since every class method is stored in a metaclass. That’s simply just how it works. Which is why you can also use self class MailTruck def self.add( truck ) @@trucks truck end end Or the singleton syntax class MailTruck class self def add( truck ) @@trucks truck end end end Class instance variables and metaclass instance methods are really pretty pointless in a plain old class. But when inheritance enters the mix, the party comes alive. Writhing bodies and drunken madness, believe me. class MailTruck def self.company( name ) meta_def company do; name; end end end The above method is remarkably simple, but excavates a beachhead worth of possibilities. A new company class method is added to MailTruck that can be used in a class definition. class HappyTruck MailTruck company Happy s -- We Bring the Mail, and That s It! end Okay, so the company class method gets executed with the Happy’s company name and slogan. What does meta_def do with it?? Well, the meat of meta arrives here. The meta_def adds a new method called company to the HappyTruck metaclass. The beauty of this is that the method is not added to the MailTruck metaclass, but to the derived class HappyTruck. This may seem simple, but it’s very powerful. You can write simple class methods which will add class methods to a derived class. This is the secret to Rails and Ruby/X11 and so many other examples of metaprogramming in Ruby. Dwemthy’s Array Ruby本のためにDwemthyのArrayを作っているときに大部分を発見しました。 私は作成したコードをここまでシンプルにすることが出来ました。( RPG で読みやすく) ： class Creature def self.traits( *arr ) return @traits if arr.empty? attr_accessor *arr arr.each do |trait| meta_def trait do |val| @traits ||= {} @traits[trait] = val end end class_def initialize do self.class.traits.each do |k,v| instance_variable_set( @#{k} , v ) end end end end meta_def と class_def はメタプログラミングをちょっとわかりやすくするのを助けます。 meta_def のインスタンス変数の使い方に注意してください。 この状況でクラス変数がどうして動作しないのか理解したいなら、 インスタンス変数をクラス変数に変えてみてください。 次に、Dwemthy の Array ページで説明されている怪物を作成し始めてください。そうすれば全体を確認できるでしょう。
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Market Synopsis Market Research Future (MRFR) conducted study on the Identity as a Service Market Segments 2020 and detailed insights into the effect of COVID pandemic on the market in the report. According to MRFR analysis, the identity as a service (IDaaS) market can rise at 18.4% CAGR across the forecast period. By 2027, the identity as a service (IDaaS) market value can cross USD 10 Bn. The growing deployment of IDaaS on largely accepted cloud platform can boost the expansion of the IDaaS market across the review period. The increase in the adoption of SaaS-based IAM offerings that allow organizations to use single sign-on (SSO) via OpenID Connect (OIDC) or Security Assertion Markup Language (SAML) for the authentication and access controls to provide secured access to enterprises' SaaS applications can promote the expansion of the world market of IDaaS. The growing need to curb on-site infrastructure that can support a wide range of integration options can boost the expansion of the IDaaS market. The rise in the level of interconnectivity as IoT and BYOD culture are trending across different verticals can bolster the expansion of the IDaaS market. Rise in IDaaS vendors can also benefit the global market. The high utility of DevSecOps practices for the identification and access management in organizations can fuel the expansion of the market growth. The growing concerns of companies regarding data security limit is pressing the need for IDaaS solutions that can promote the expansion of the global identity as a service (IDaaS) market in the years to come. The rise in preference for on-premise access management systems can pose threat to the IDaaS market. Request a Free Sample @ https //www.marketresearchfuture.com/sample_request/7928 Market Segmentation The segments study of the global IDaaS market is based on deployment, service, organization size, and vertical. The service-based, the global IDaaS market segments are access, identity governance administration, and intelligence. The organization size based, the global IDaaS market segments are large enterprise and small- and medium-sized enterprise (SME). The deployment based, the global IDaaS market segments are public cloud, private cloud, and hybrid. The vertical based, the global IDaaS market segments are BFSI, retail and CPG, manufacturing, energy and utilities, transportation, healthcare and life sciences, and government and defense among others. Regional Analysis North America IDaaS market is expected to secure the highest global market size in the forecast period. Led by the US, the market in North America can rise exponentially due to the early adoption of DevSecOps that aids in the identification and allows access to management and strict government directives associated with data protection. The increase in cyber threats and high growing demand for potential and powerful authentication solutions on cloud can drive the IDaaS market in North America. In Asia Pacific, the IDaaS market can expand rapidly in evaluation period. The growing BYOD trend and increase in IoT applications across verticals and increase in the awareness among enterprises regarding security issues can promote the IDaaS market in the Asia Pacific region. APAC is observed to hold high growth prospects, thus the expansion of the IDaaS market in the Asia Pacific region is expected to rise substantially. Key Players MRFR identified some notable players of the global IDaaS market. They are; Okta, Inc. (US), Avatier (US), OneLogin, Inc (US), Fischer Identity (US), Microsoft Corporation, (US), Oracle Corporation (US), Centrify Corporation (US), Ping Identity (US), iWelcome (Netherlands), empowerID (US),VMWare (US), LoginRadius (Canada), IDaptive, LLC. (US), Ubisecure, Inc. (Finland), Sailpoint (US), Optimal IdM(US), Bitium, Inc. (US), and others. These players are recognized by origin, regional presence, recent key innovations, industry expertise, and product diversification. Access Report Details @ https //www.marketresearchfuture.com/reports/identity-service-market-7928 Table of Contents 1 Executive Summary 2 Scope of The Report 2.1 Market Definition 2.2 Scope of The Study 2.2.1 Research Objectives 2.2.2 Assumptions Limitations 2.3 Markets Structure 3 Market Research Methodology 3.1 Research Process 3.2 Secondary Research 3.3 Primary Research 3.4 Forecast Model Continued… Similar Report B2B Telecommunication Market Forensic Accounting Market Trending #MRFR Report** https //ictmrfr.blogspot.com/2022/04/geofencing-market-companies-growth-with.html https //blogfreely.net/pranali004/telecom-expense-management-market-size-impressive-cagr-changing-business-scope https //postheaven.net/pranali004/financial-app-industry-impressive-cagr-changing-business-needs-scope-of https //market-research-future.tribe.so/post/openstack-service-market-research-impressive-cagr-changing-scope-of-current--6263de46791566c10c79891e https //www.scutify.com/articles/2022-04-24-infrastructure-as-a-service-industry-cagr-changing-business-scope-of-current-and-future-industry- About Market Research Future At Market Research Future (MRFR), we enable our customers to unravel the complexity of various industries through our Cooked Research Report (CRR), Half-Cooked Research Reports (HCRR), Raw Research Reports (3R), Continuous-Feed Research (CFR), and Market Research Consulting Services. Contact Market Research Future (Part of Wantstats Research and Media Private Limited) 99 Hudson Street, 5Th Floor New York, NY 10013 United States of America 1 628 258 0071 (US) 44 2035 002 764 (UK) Email sales@marketresearchfuture.com Website https //www.marketresearchfuture.com
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SYK deficient mice show defective in phagocytosis of macrophages and in generaction of reactive oxygen intermediates of neutrophils. ZAP-70 deficient mice impair the developmnt of NK1.1+ alpha beta T cells. ITK-/- mice reduce mast cell degranulation and acute allergic responses. Vav-2,3(-/-) neurons exhibit impaired axon guidance. Vav-1(-/-) NK cells are dramactically diminished 2B4 PLCG2-deficient mice exhibit a loss of collagen-induced platelet aggregation, mast cell FcepsilonR function, and NK cell FcgammaRIII and 2B4 function. GAB3 has no effect for phenotype. GAB2 deficient mast cells in mice result in impaired response of Fc epsilon RI. GAB2 deficient macrophages in mice result impaired phagocytosis. SYK deficient mice show defective in phagocytosis of macrophages and in generaction of reactive oxygen intermediates of neutrophils. 1 J Exp Med. 1997 Oct 6;186(7) 1027-39. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. Crowley MT, Costello PS, Fitzer-Attas CJ, Turner M, Meng F, Lowell C, Tybulewicz VL, DeFranco AL. G.W. Hooper Foundation, University of California, San Francisco, California 94143-0552, USA. mtcrow@scripps.edu Receptors on macrophages for the Fc region of IgG (FcgammaR) mediate a number of responses important for host immunity. Signaling events necessary for these responses are likely initiated by the activation of Src-family and Syk-family tyrosine kinases after FcgammaR cross-linking. Macrophages derived from Syk-deficient (Syk-) mice were defective in phagocytosis of particles bound by FcgammaRs, as well as in many FcgammaR-induced signaling events, including tyrosine phosphorylation of a number of cellular substrates and activation of MAP kinases. In contrast, Syk- macrophages exhibited normal responses to another potent macrophage stimulus, lipopolysaccharide. Phagocytosis of latex beads and Escherichia coli bacteria was also not affected. Syk- macrophages exhibited formation of polymerized actin structures opposing particles bound to the cells by FcgammaRs (actin cups), but failed to proceed to internalization. Interestingly, inhibitors of phosphatidylinositol 3-kinase also blocked FcgammaR-mediated phagocytosis at this stage. Thus, PI 3-kinase may participate in a Syk-dependent signaling pathway critical for FcgammaR-mediated phagocytosis. Macrophages derived from mice deficient for the three members of the Src-family of kinases expressed in these cells, Hck, Fgr, and Lyn, exhibited poor Syk activation upon FcgammaR engagement, accompanied by a delay in FcgammaR-mediated phagocytosis. These observations demonstrate that Syk is critical for FcgammaR-mediated phagocytosis, as well as for signal transduction in macrophages. Additionally, our findings provide evidence to support a model of sequential tyrosine kinase activation by FcgammaR s analogous to models of signaling by the B and T cell antigen receptors. Publication Types Research Support, Non-U.S. Gov t Research Support, U.S. Gov t, P.H.S. PMID 9314552 [PubMed - indexed for MEDLINE] 1 Mol Cell Biol. 1998 Jul;18(7) 4209-20. The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils. Kiefer F, Brumell J, Al-Alawi N, Latour S, Cheng A, Veillette A, Grinstein S, Pawson T. Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5. The cytoplasmic protein tyrosine kinase Syk has two amino-terminal SH2 domains that engage phosphorylated immunoreceptor tyrosine-based activation motifs in the signaling subunits of immunoreceptors. Syk, in conjunction with Src family kinases, has been implicated in immunoreceptor signaling in both lymphoid and myeloid cells. We have investigated the role of Syk in Fcgamma receptor (FcgammaR)-dependent and -independent responses in bone marrow-derived macrophages and neutrophils by using mouse radiation chimeras reconstituted with fetal liver cells from Syk-/- embryos. Chimeric mice developed an abdominal hemorrhage starting 2 to 3 months after transplantation that was ultimately lethal. Syk-deficient neutrophils derived from the bone marrow were incapable of generating reactive oxygen intermediates in response to FcgammaR engagement but responded normally to tetradecanoyl phorbol acetate stimulation. Syk-deficient macrophages were defective in phagocytosis induced by FcgammaR but showed normal phagocytosis in response to complement. The tyrosine phosphorylation of multiple cellular polypeptides, including the FcgammaR gamma chain, as well as Erk2 activation, was compromised in Syk-/- macrophages after FcgammaR stimulation. In contrast, the induction of nitric oxide synthase in macrophages stimulated with lipopolysaccharide and gamma interferon was not dependent on Syk. Surprisingly, Syk-deficient macrophages were impaired in the ability to survive or proliferate on plastic petri dishes. Taken together, these results suggest that Syk has specific physiological roles in signaling from FcgammaRs in neutrophils and macrophages and raise the possibility that in vivo, Syk is involved in signaling events other than those mediated by immunoreceptors. Publication Types Research Support, Non-U.S. Gov t PMID 9632805 [PubMed - indexed for MEDLINE] ZAP-70 deficient mice impair the developmnt of NK1.1+ alpha beta T cells. 1 Immunol Lett. 2000 Jul 3;73(1) 65-9. Induction of NK1.1(+) alpha beta TCR(+) T cells by bypassing TCR signals in ZAP-70 deficient mice. Tone S, Iwabuchi K, Iwabuchi C, Negishi I, Onoe K. Division of Immunobiology, Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Kita-15 Nishi-7, Kita-Ku, Sapporo 060-0815, Japan. The mechanism of development of a unique subset of T cells, thymic NK1.1(+) alpha beta T cells, has been poorly understood. We found that the development of thymic NK1.1(+) alpha beta T cells was defective in mice deficient in ZAP-70. Instead, an accumulation of NK1.1(+) TCR beta(-) NK-like population was detected in the thymus and spleen of the ZAP-70 deficient (ZAP -/-) mouse. In the present report, we examined whether biochemical treatments that replace TCR-mediated positive selection signals could restore the generation of thymic NK1.1(+) alpha beta T cells in ZAP -/- mice using the thymus organ culture. We found that a higher concentration of phorbol ester (PMA) than that required for CD4(+) T cell generation and ionomycin induced the generation of NK1.1(+) alpha beta T cells. Phenotypic analysis of the induced NK1.1(+) alpha beta T cell population suggested that these cells expressed CD8 but not CD4 molecules, which is a different characteristic from ordinary thymic NK1.1(+) alpha beta T cells. These results suggest that differential signaling is required for the generation of mainstream T cells and thymic NK1.1(+) alpha beta T cells. PMID 10963813 [PubMed - indexed for MEDLINE] ITK-/- mice reduce mast cell degranulation and acute allergic responses. 1 Am J Respir Cell Mol Biol. 2005 Jun;32(6) 511-20. Epub 2005 Mar 18. Interleukin-2-inducible T cell kinase regulates mast cell degranulation and acute allergic responses. Forssell J, Sideras P, Eriksson C, Malm-Erjefalt M, Rydell-Tormanen K, Ericsson PO, Erjefalt JS. Transplantation Center, Foundation for Biomedical Research, Academy of Athens, Athens, Greece. Bruton s tyrosine kinase (Btk) is thought to positively regulate mast cell activation, implying a role in allergic responses. We have compared acute and late phase allergic airway reactions in mice lacking either Btk or interleukin-2-inducible T cell kinase (Itk), another Tec kinase expressed in mast cells. Btk(-/-) mice showed minor protection against allergic symptoms when challenged with allergen via the airways. In sharp contrast, both acute and late phase inflammatory allergic responses were markedly reduced in Itk(-/-) mice. Notably, airway mast cell degranulation in Itk(-/-) mice was severely impaired, despite wild-type levels of allergen-specific IgE and IgG1. The degranulation defect was confirmed in DNP-conjugated human serum albumin-challenged mice passively sensitized with anti-DNP IgE antibodies, and was also observed after direct G-protein stimulation with the mast cell secretagogue c48/80. Moreover, late phase inflammatory changes, including eosinophilia, lymphocyte infiltration, and Th2 cytokine production in the lungs, was eliminated in Itk(-/-) mice. Collectively, our data suggest a critical role of Itk in airway mast cell degranulation in vivo that together with an impaired T cell response prevents the development of both acute and late phase inflammatory allergic reactions. Publication Types Research Support, Non-U.S. Gov t PMID 15778496 [PubMed - indexed for MEDLINE] Vav-2,3(-/-) neurons exhibit impaired axon guidance. 1 Neuron. 2005 Apr 21;46(2) 205-17. Comment in Vav family GEFs link activated Ephs to endocytosis and axon guidance. Cowan CW, Shao YR, Sahin M, Shamah SM, Lin MZ, Greer PL, Gao S, Griffith EC, Brugge JS, Greenberg ME. Neurobiology Program, Children s Hospital, Boston, Massachusetts 02115, USA. Ephrin signaling through Eph receptor tyrosine kinases can promote attraction or repulsion of axonal growth cones during development. However, the mechanisms that determine whether Eph signaling promotes attraction or repulsion are not known. We show here that the Rho family GEF Vav2 plays a key role in this process. We find that, during axon guidance, ephrin binding to Ephs triggers Vav-dependent endocytosis of the ligand-receptor complex, thus converting an initially adhesive interaction into a repulsive event. In the absence of Vav proteins, ephrin-Eph endocytosis is blocked, leading to defects in growth cone collapse in vitro and significant defects in the ipsilateral retinogeniculate projections in vivo. These findings suggest an important role for Vav family GEFs as regulators of ligand-receptor endocytosis and determinants of repulsive signaling during axon guidance. Publication Types PMID 15848800 [PubMed - indexed for MEDLINE] Vav-1(-/-) NK cells are dramactically diminished 1 Eur J Immunol. 2001 Aug;31(8) 2403-10. Vav-1 regulates NK T cell development and NK cell cytotoxicity. Chan G, Hanke T, Fischer KD. Abteilung Physiologische Chemie, Universitat Ulm, Ulm, Germany. The hematopoietic-specific Rho-family GTP exchange factor Vav-1 is a regulator of lymphocyte antigen receptor signaling and mediates normal maturation and activation of B and T cells.Recent findings suggest that Vav-1 also forms part of signaling pathways required for natural and antibody dependent cellular cytotoxicity (ADCC) of human NK cells. In this study, we show that Vav-1 is also expressed in murine NK cells. Vav-1(-/-) mice had normal numbers of splenic NK cells, and these displayed a similar expression profile of NK cell receptors as wild-type mice. Unexpectedly, IL-2-activated Vav-1(-/-) NK cells retained normal ADCC. Fc-receptor mediated activation of ERK, JNK, and p38 was also normal. In contrast, Vav-1(-/-) NK cells exhibited reduced natural cytotoxicity against EL4, C4.4.25, RMA and RMA/S. Together, the results demonstrate that Vav-1 is dispensable for mainstream NK cell development, but is required for NK natural cytotoxicity. Unlike the findings for NK cells, NK T cells were dramatically diminished in Vav-1(-/-) mice and splenocytes from Vav-1 mutant mice failed to produce IL-4 in response to in vivo CD3 stimulation. These data highlight the important role of Vav-1 in NK T cell development and NK cell function. Publication Types Research Support, Non-U.S. Gov t PMID 11500824 [PubMed - indexed for MEDLINE] 2B4 2B4 is a cell-surface glycoprotein related to CD2 and implicated in the regulation of natural killer and T-lymphocyte function. It appears that the primary function of 2B4 is to modulate other receptor-ligand interactions to enhance leukocyte activation. PLCG2-deficient mice exhibit a loss of collagen-induced platelet aggregation, mast cell FcepsilonR function, and NK cell FcgammaRIII and 2B4 function. 1 Immunity. 2000 Jul;13(1) 25-35. Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. Wang D, Feng J, Wen R, Marine JC, Sangster MY, Parganas E, Hoffmeyer A, Jackson CW, Cleveland JL, Murray PJ, Ihle JN. Department of Biochemistry, St. Jude Children s Research Hospital, Memphis, Tennessee 38105, USA. Many receptors activate phospholipase Cgamma1 or -gamma2. To assess the role of PLCgamma2, we derived enzyme-deficient mice. The mice are viable but have decreased mature B cells, a block in pro-B cell differentiation, and B1 B cell deficiency. IgM receptor-induced Ca2+ flux and proliferation to B cell mitogens are absent. IgM, IgG2a, and IgG3 levels are reduced, and T cell-independent antibody production is absent. The similarity to Btk- or Blnk-deficient mice demonstrates that PLCgamma2 is downstream in Btk/Blnk signaling. FcRgamma signaling is also defective, resulting in a loss of collagen-induced platelet aggregation, mast cell FcepsilonR function, and NK cell FcgammaRIII and 2B4 function. The results define a signal transduction pathway broadly utilized by immunoglobulin superfamily receptors. Publication Types PMID 10933392 [PubMed - indexed for MEDLINE] GAB3 has no effect for phenotype. 1 Mol Cell Biol. 2003 Apr;23(7) 2415-24. Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent. Seiffert M, Custodio JM, Wolf I, Harkey M, Liu Y, Blattman JN, Greenberg PD, Rohrschneider LR. Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA. Gab proteins are intracellular scaffolding and docking molecules involved in signaling pathways mediated by various growth factor, cytokine, or antigen receptors. Gab3 has been shown to act downstream of the macrophage colony-stimulating factor receptor, c-Fms, and to be important for macrophage differentiation. To analyze the physiological role of Gab3, we used homologous recombination to generate mice deficient in Gab3. Gab3(-/-) mice develop normally, are visually indistinguishable from their wild-type littermates, and are healthy and fertile. To obtain a detailed expression pattern of Gab3, we generated Gab3-specific monoclonal antibodies. Immunoblotting revealed a predominant expression of Gab3 in lymphocytes and bone marrow-derived macrophages. However, detailed analysis demonstrated that hematopoiesis in mice lacking Gab3 is not impaired and that macrophages develop in normal numbers and exhibit normal function. The lack of Gab3 expression during macrophage differentiation is not compensated for by increased levels of Gab1 or Gab2 mRNA. Furthermore, Gab3-deficient mice have no major immune deficiency in T- and B-lymphocyte responses to protein antigens or during viral infection. In addition, allergic responses in Gab3-deficient mice appeared to be normal. Together, these data demonstrate that loss of Gab3 does not result in detectable defects in normal mouse development, hematopoiesis, or immune system function. PMID 12640125 [PubMed - indexed for MEDLINE] GAB2 deficient mast cells in mice result in impaired response of Fc epsilon RI. 1 Nature. 2001 Jul 12;412(6843) 186-90. Essential role for Gab2 in the allergic response. Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG. Cancer Biology Program, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA hgu@caregroup.harvard.edu. Dos/Gab family scaffolding adapters (Dos, Gab1, Gab2) bind several signal relay molecules, including the protein-tyrosine phosphatase Shp-2 and phosphatidylinositol-3-OH kinase (PI(3)K); they are also implicated in growth factor, cytokine and antigen receptor signal transduction. Mice lacking Gab1 die during embryogenesis and show defective responses to several stimuli. Here we report that Gab2-/- mice are viable and generally healthy; however, the response (for example, degranulation and cytokine gene expression) of Gab2-/- mast cells to stimulation of the high affinity immunoglobulin-epsilon (IgE) receptor Fc(epsilon)RI is defective. Accordingly, allergic reactions such as passive cutaneous and systemic anaphylaxis are markedly impaired in Gab2-/- mice. Biochemical analyses reveal that signalling pathways dependent on PI(3)K, a critical component of Fc(epsilon)RI signalling, are defective in Gab2-/- mast cells. Our data identify Gab2 as the principal activator of PI(3)K in response to Fc(epsilon)RI activation, thereby providing genetic evidence that Dos/Gab family scaffolds regulate the PI(3)K pathway in vivo. Gab2 and/or its associated signalling molecules may be new targets for developing drugs to treat allergy. PMID 11449275 [PubMed - indexed for MEDLINE] GAB2 deficient macrophages in mice result impaired phagocytosis. 1 J Cell Biol. 2003 Jun 23;161(6) 1151-61. Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis. Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG. Harvard Institutes of Medicine, 77 Ave. Louis Pasteur, HIM 1047 Boston, MA 02115, USA. hgu@caregroup.harvard.edu Grb2-associated binder 2 (Gab2), a member of the Dos/Gab subfamily scaffolding molecules, plays important roles in regulating the growth, differentiation, and function of many hematopoietic cell types. In this paper, we reveal a novel function of Gab2 in Fcgamma receptor (FcgammaR)-initiated phagocytosis in macrophages. Upon FcgammaR activation, Gab2 becomes tyrosyl phosphorylated and associated with p85, the regulatory subunit of phosphoinositide 3-kinase (PI3K), and the protein-tyrosine phosphatidylinositol Shp-2. FcgammaR-mediated phagocytosis is severely impaired in bone marrow-derived macrophages from Gab2-/- mice. The defect in phagocytosis correlates with decreased FcgammaR-evoked activation of Akt, a downstream target of PI3K. Using confocal fluorescence microscopy, we find that Gab2 is recruited to the nascent phagosome, where de novo PI3K lipid production occurs. Gab2 recruitment requires the pleckstrin homology domain of Gab2 and is sensitive to treatment with the PI3K inhibitor wortmannin. The Grb2 binding site on Gab2 also plays an auxiliary role in recruitment to the phagosome. Because PI3K activity is required for FcgammaR-mediated phagocytosis, our results indicate that Gab2 acts as a key component of FcgammaR-mediated phagocytosis, most likely by amplifying PI3K signaling in the nascent phagosome. PMID 12821647 [PubMed - indexed for MEDLINE]