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GENRE TITLE ARTIST bpm notes CLEAR RATE JAZZ ROCK 1001 -ESCAPE- SOUND HOLIC feat. Nana Takahashi 147 n%（yyyy/mm/dd） 攻略・コメント ハネていてひっかけ気味のリズム取りも多い。皿同時がかなり多いが階段はそれほど出てこない -- 名無しさん (2018-02-27 17 05 10) 名前 コメント
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GENRE TITLE ARTIST bpm notes CLEAR RATE NU DRUM BASS Wonderful Escape DÉ DÉ MOUSE 165 744 92.6%（2022/10/18） 攻略・コメント 中盤にある1バス地帯から13交互地帯と出口の短い軸が完全に☆8。その後も16分の階段と同時押し+皿、くの字が何度もゲージを削ってくるため立て直しがしづらくシンプルに難しい。 -- 名無しさん (2022-03-28 09 54 22) 名前 コメント
https://w.atwiki.jp/apex/pages/46.html
Heat Shock Protein HSP70 Selbex Iressa http //wwwsoc.nii.ac.jp/jrr/japanese/paper/paper2007_5.htm Heat Shock Protein 70 Increases Tumorigenicity and Inhibits Apoptosis in Pancreatic Adenocarcinoma 慶應義塾大学薬学部 水島徹教授 http //www.keio.ac.jp/ja/press_release/2011/kr7a43000007v2jzatt/111020_1.pdf Selbex Teprenone geranylgeranylacetone
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Heat Shock Protein Heat Shock Protein 70 Increases Tumorigenicity and Inhibits Apoptosis in Pancreatic Adenocarcinoma http //wwwsoc.nii.ac.jp/jrr/japanese/paper/paper2007_5.htm HSP70 Selbex Iressa 慶應義塾大学薬学部 水島徹教授 http //www.keio.ac.jp/ja/press_release/2011/kr7a43000007v2jz-att/111020_1.pdf Selbex Teprenone geranylgeranylacetone
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※(Full Of Harmony) このまま its crusing time 君を乗せて Baby Let s take a ride! all right どこまでも Escape 通り過ぎていく景色を 染めるスカイブルー Baby Let s take a ride! all right 気の向くまま Escape※ day light ゆるやかに 降り注ぐ ウィークエンド こんな日は It s private time たまには slow down 時計なんて今日は気にしないで LOW GEAR ながす湾岸LINE 波の音に身を任せよう Oh my baby (ZEEBRA) Let s take a ride さあ Baby 逃げ出そうぜ 気づかれる前に消えちゃおうぜ クレイジーな街でのクレイジーなダチとの クレイジーなパーティーならまた来週 U know? 二人パラダイスムード U know? このまま終わらないクルーズ 息苦しい街を大脱走 携帯 オフ iPod オン ジャジーなプレイリスト Miles Davis それとも軽く Go back to 80 s Whitney Houston Patti Labelle 風が君の髪を掻き上げる サンルーフ オープン So I can feel the wind blow 君とキスする赤信号 最高気持ちいいこの感じ まるで 夢ん中で見たあのワンシーン (ゆっくりと 時が流れてく) 光るオーシャン すべてスローモーション (Nice Slow すべて脱ぎ捨ててく) That s right Take everything off (Full Of Harmony) Do what comes naturally 広がる二人だけの Beautiful Day Oh lalalala 夢の中 it s tack a one more time Make it last forever まるでKeath Sweat 夢が覚めたって 君はプリンセス フリーウェイ 日めくりめくる風の方向で Chill して眠るだけ 沈むサンセット オレンジからパープル 空に冷えたシャンパンがスパークル I feel good, baby ポエマーばりだって? 大丈夫 I m still hood, baby ただこのナチュラルヴァイブス たまに味わえなきゃ始まらない それが人間 野生の証明 海と山 空と大地と共鳴 全て元々繋がってる (U know?) 何かが欠けて塞がってる (U know?) 夜もいっそうに深まってる そう 俺たちも繋がろう さあ Let s go (※くり返し)
https://w.atwiki.jp/michealfeng/pages/24.html
Paper bag producers maximize the enhancements in know-how to produce and make different collections of paper bags from the industry. This provides companies extra options to design and style their luggage according for their company s ideals. From the enterprise identify and brand on the design and style, artwork and also other design technical specs, companies will find excellent luggage that meet up with their wanted appear. The paper market has produced each bao bao issey miyake and every form of bag you could think about - recycled, glossy and laminated, handmade, purely natural brown and bleached white, synthetic, flipside, and a great deal far more! They are just the type of paper employed. There are actually however the assortments in colour, shapes and sizes. Paper bag producers can assist you market your company with the usage of these baggage. They can be your store s provider or searching bags, gift luggage or loot baggage. With bags of all types, particularly when printed with the brand, are effective marketing products. This method is probably the easiest, most hassle-free promoting software you may employ. The levels of competition while in the paper luggage market effects not just in more and greater alternatives than ever before before, but will also more aggressive prices. Paper solutions are generally more affordable. They actually have several of the ideal promotions within the marketplace. Most brands provide savings for bulk orders, for returning and/or long-time shoppers. Paper bag companies staff up with organizations to fulfill organization prerequisites in high quality, provider, profits and publicity. Advertising worries push these manufacturers to increase previously mentioned and stick out from among the their competition to generally be the top at their craft. It can be regular to seek out brands tailoring specific courses to accommodate clients needs. The retail businesses for example, capitalize on retail baggage, as these are vital of their merchandising where targeted traffic, profits and profits are increased. Sure, these baggage in all forms and uses can in fact do this to your company. Quite a few of such brands are big firms with various factories and suppliers worldwide. They include things like printing, support, and distribution to associates to higher deal with the wants of enterprise clients. Speedy and affordable shipping replica dior of paper bags are about the best in the checklist like a reflection of productive provider. In executing so, brands assurance their associates and purchasers a dependable offer with the needed luggage that you choose to need. Just after all, how can a retailer have these luggage with out a dependable paper bag producer to deliver for them? In maintaining with all the environmental awareness campaigns globally, paper bag producers truly feel correct at your home with paper as their main raw material. Manufacturing is also much more eco-friendly, notably with recycled luggage. An increasing number of producers and suppliers capitalize on recycled items as their advertising place, which also adds to favorable feed-back from your communities they serve. Since they get more assist with the general public, so to perform earnings get a optimistic convert. Organizations may also be welcoming recycled paper bags on their own group as being a a lot more conscientious phase to environmental advocacy. We see shops like guide outlets, cafes, restaurants and boutiques employing not simply extravagant paper carrier bags but recycled kinds also. There are such a lot of paper bag producers to settle on from. They all have a typical aim anyway. That is, to make paper luggage that can assistance the assorted enterprise sectors regardless of whether it is really in foodstuff, retail, technologies or arts. These bags are valuable, eco-friendly and much more economical choices for shoppers. The market is plainly escalating. Be in the forefront of the trend.
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autolink 姿分け/Shapesharer (１)(青) クリーチャー ― 多相の戦士(Shapeshifter) 多相（このカードは、常にすべてのクリーチャー・タイプである。） (２)(青)：多相の戦士(Shapeshifter)１つとクリーチャー１体を対象とする。前者は、あなたの次のターンまで後者のコピーになる。 1/1 《姿分け/Shapesharer》をGathererで確認 《姿分け/Shapesharer》をGoogleで検索 《姿分け/Shapesharer》が使用された大会 取得中です。 カードテキスト転載元：Wisdom Guild様 2012 / 10 / 01
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metformin Metformin use and improved response to therapy in esophageal adenocarcinoma http //stemcellstm.alphamedpress.org/gca?allch= submit=Go gca=sctm%3Bsctm.2012-0058v1 Stem Cells Translational Medicine Cancer Stem Cells Glioma-Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK Atsushi Sato, Jun Sunayama, Masashi Okada, Eriko Watanabe, Shizuka Seino, Keita Shibuya, Kaori Suzuki, Yoshitaka Narita, Soichiro Shibui, Takamasa Kayama, Chifumi Kitanaka Stem Cells Trans Med first published on November 15, 2012; doi 10.5966/sctm.2012-0058 Cancer Stem Cells Glioma-Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK Control of the cancer stem/initiating cell population is considered key to realizing the long-term survival of glioblastoma patients. Recently, we demonstrated that FOXO3 activation is sufficient to induce differentiation of glioma-initiating cells having stem-like properties and inhibit their tumor-initiating potential. Here we identified metformin, an antidiabetic agent, as a therapeutic activator of FOXO3. Metformin activated FOXO3 and promoted differentiation of such stem-like glioma-initiating cells into nontumorigenic cells. Furthermore, metformin promoted FOXO3 activation and differentiation via AMP-activated protein kinase (AMPK) activation, which was sensitive to extracellular glucose availability. Importantly, transient, systemic administration of metformin depleted the self-renewing and tumor-initiating cell population within established tumors, inhibited tumor formation by stem-like glioma-initiating cells in the brain, and provided a substantial survival benefit. Our findings demonstrate that targeting glioma-initiating cells via the AMPK-FOXO3 axis is a viable therapeutic strategy against glioblastoma, with metformin being the most clinically relevant drug ever reported for targeting of glioma-initiating cells. Our results also establish a novel, direct link between glucose metabolism and cancer stem/initiating cells. Metformin May Lower Risk for Oral Cancer Development ScienceDaily (Mar. 31, 2012) http //www.sciencedaily.com/releases/2012/03/120331151138.htm http //www.news-medical.net/ http //www.news-medical.net/news/2007/08/16/28828.aspx Metformin kills some cancer cells Researchers at the University of Pennsylvania School of Medicine have found that a commonly prescribed diabetes drug kills tumor cells that lack a key regulatory gene called p53. http //www.ncbi.nlm.nih.gov/pmc/articles/PMC2756324/ Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission OCT1 organic cation transporter-1 Human OCT1 is mainly expressed in the liver. LKB1 AMPK OCT2 hOCT2 - human kidney mTOR http //ds-pharma.jp/medical/ebiz/metgluco/gold_standard/012/book.pdf Polycystic Ovarian Syndrome(PCOS) http //cancerpreventionresearch.aacrjournals.org/ 乳腺腫瘍内科医のミシガン大学ポスドク留学日記 http //tkhawkeye.blog.fc2.com/blog-entry-284.html メトホルミンの作用機序は、ミトコンドリア内での酸化還元反応を抑制することでAMP→ATPへの移行を抑制する。その結果AMP優位となり、AMP-activated protein kinase（AMPK）が活性化される。その結果糖代謝の亢進やグルコースのuptakeが起こるわけだが、それと同時にmTORのカスケードを構成する因子であるRaptorやTSCを抑制することによりタンパク質の産生を抑制する。mTORはインスリンレセプターからmTOR、AKTと至るタンパク合成を促進する細胞内カスケードの中間の経路を担っているが、メトホルミンによるmTORの直接的あるいは間接的な抑制もこの経路を介した細胞増殖を抑制することにつながっている。 Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP Russell A. Miller, Qingwei Chu, Jianxin Xie, Marc Foretz, Benoit Viollet Morris J. Birnbaum Nature 494, 256–260 (14 February 2013) Glucose production by the liver is essential for providing a substrate for the brain during fasting. The inability of insulin to suppress hepatic glucose output is a major aetiological factor in the hyperglycaemia of type-2 diabetes mellitus and other diseases of insulin resistance1, 2. For fifty years, one of the few classes of therapeutics effective in reducing glucose production has been the biguanides, which include phenformin and metformin, the latter the most frequently prescribed drug for type-2 diabetes3. Nonetheless, the mechanism of action of biguanides remains imperfectly understood. The suggestion a decade ago that metformin reduces glucose synthesis through activation of the enzyme AMP-activated protein kinase (AMPK) has recently been challenged by genetic loss-of-function experiments4. Here we provide a novel mechanism by which metformin antagonizes the action of glucagon, thus reducing fasting glucose levels. In mouse hepatocytes, metformin leads to the accumulation of AMP and related nucleotides, which inhibit adenylate cyclase, reduce levels of cyclic AMP and protein kinase A (PKA) activity, abrogate phosphorylation of critical protein targets of PKA, and block glucagon-dependent glucose output from hepatocytes. These data support a mechanism of action for metformin involving antagonism of glucagon, and suggest an approach for the development of antidiabetic drugs. apex @ ウィキ http //www10.atwiki.jp/apex/
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74 名前：ORGASM ：2005/12/26(月) 18 11 47 ID ??? [曲 名] Snowscape feat. 司 [U R L] http //popup15.tok2.com/home2/neverland/dcnt/dcnt.cgi?n=10 [時 間] よんぷんにじゅういちびよう [曲 調] 雪景色 [テーマ] クリスマスというか冬の街並みの感じ [著作権] BlackShade, 司 track by BlackShade [保管サイトでの保管] × [コメント] 遅くなりましたがメリークリスマス。 司さんを迎えてクリスマスソング。 ハプニング連発で焦りました。 苦労してつくたので聞いてくださいな。
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"How important is rape in Japan?" 「日本でレイプはどのくらい重要なのか？」 June 11, 2008 J@pan Inc Blog Anna Kitanaka Today a story appeared on the Mainichi Online front page Man arrested for raping woman in western Tokyo. The man has been arrested for a rape that happened in early April and there is the suggestion that he could be the wanted suspect for another attempted rape that happened in mid-May in Tachikawa. 今日、あるニュースが毎日オンラインのトップページに載った：男が西東京で女性をレイプした容疑で逮捕。男は4月初めに起こったレイプですでに逮捕されており、5月の半ばに立川で起こった別のレイプ事件でも容疑がかけられているという。 However, even if he is charged for two of rapes, technically he would not be counted as a serial rapist (which is usually three or more), which raises the question—why was this news story chosen over numerous other rapes that happen in Japan? Do the Mainichi reporters know more than they are telling us and suspect him to be a serial rapist? Or with rape cases decreasing in Japan, has this crime become even more important in Japanese society? しかしながら、彼が2件のレイプ容疑がかけられているとしても、実際のところ、彼は3件やそれ以上の事件を起こす連続レイプ犯ではないようだ。ここで疑問なのは、なぜ日本における数あるレイプ事件の中から、このニュースが選ばれたのかだ。毎日新聞のリポーターは報道した以上のことを知っていて、彼を連続レイプ犯だと疑っているのだろうか？あるいは、日本ではレイプ事件が減っているため、日本社会でこの事件はより重要なものになったのだろうか？ Take the UK for example. Home Office statistics state that there were 13,322 reports of rape (of a female) in 2004/2005. In Japan, according to the National Police Agency, this number is 2,076 for the same year. And this number has decreased to 1,948 (-6.2%) in 2006. 英国を例にとってみよう。内務省の統計によると、2004年/2005年に（女性の）レイプ事件は13,322件報告されている。 日本では、警視庁によると、この数は同じ年で2,076件である。そしてこの数は2006年には1,948件（-6.2%）に減少している。 In the UK, a crime such as this would not “merit importance” in a national newspaper, as cases like these are all too frequent. However, with low statistics such as these in Japan, is this report actually a reflection of Japan’s safety? 英国では、このような犯罪は全国紙で報じられるような"重要な価値"を持ったものと見なされていない。このような事件はありきたり過ぎるからだ。しかしながら、日本ではこのような事件が統計上少ないため、この報道は日本の安全性の反映なのだろうか？ Mainichi Article http //mdn.mainichi.jp/national/news/20080610p2a00m0na005000c.html